Frailty is a biologic state of decreased physiologic reserve and increased vulnerability to stress, intrinsically linked to every aspect of life with decompensated cirrhosis. The catabolic nature of cirrhosis leads to insidious extra-hepatic effects such as muscle wasting, malnutrition, and functional impairments that compromise the health and wellbeing of each person affected. In the ambulatory setting, the chronic biologic state of decreased physiologic reserve and increased vulnerability to stressors has been operationalized using the Liver Frailty Index (LFI) and is now a well-accepted objective construct in hepatology and transplant care. The American Society of Transplantation (AST) endorsed the use of standardized frailty metrics including LFI for ambulatory liver transplant evaluation in 2019.

中文翻译：

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测量失代偿性肝硬化中急性疾病衍生衰弱 (AIDF) 的收费

虚弱是一种生理储备减少和对压力脆弱性增加的生物学状态，与失代偿性肝硬化患者生活的方方面面都有内在联系。肝硬化的分解代谢性质会导致隐匿的肝外效应，例如肌肉萎缩、营养不良和功能障碍，这些都会损害每个受影响者的健康和福祉。在门诊环境中，生理储备减少和对应激源的脆弱性增加的慢性生物学状态已使用肝脏衰弱指数 (LFI) 进行操作，现在已成为肝脏病学和移植护理中广为接受的客观结构。美国移植学会 (AST) 于 2019 年批准使用包括 LFI 在内的标准化衰弱指标进行门诊肝移植评估。