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One-Pot Three-Component Synthesis of 2-Methyl-3-aminobenzofurans Using Calcium Carbide as a Concise Solid Alkyne Source
Chinese Journal of Chemistry ( IF 5.4 ) Pub Date : 2021-08-01 , DOI: 10.1002/cjoc.202100383
Xiaolong Ma 1 , Zhiqiang Wang 1 , Zhenrong Liu 1 , Zheng Li 1
Affiliation  

A one-pot three-component method for the synthesis of 2-methyl-3-aminobenzofurans using calcium carbide as a concise solid alkyne source, and salicylaldehydes and secondary amines as starting materials is described. This protocol has salient feature of the use of inexpensive, abundant and easy-to-handle alkyne source, avoiding the use of inflammable and explosive acetylene gas as an original alkyne source. In addition, step economy, satisfactory yield, and simple work-up procedure are also advantages of this route.image

中文翻译:

以碳化钙为简明固体炔烃源一锅法三组分合成 2-甲基-3-氨基苯并呋喃

描述了一种以碳化钙为简明固体炔烃源,以水杨醛和仲胺为原料合成 2-甲基-3-氨基苯并呋喃的一锅三组分法。该协议的显着特点是使用廉价、丰富和易于处理的炔烃源,避免使用易燃易爆的乙炔气体作为原始炔烃源。此外,步骤经济、收率令人满意、后处理程序简单也是该路线的优点。图片
更新日期:2021-08-01
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