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Alpha-band cortico-cortical phase synchronization is associated with effective connectivity in the motor network
Clinical Neurophysiology ( IF 4.7 ) Pub Date : 2021-07-30 , DOI: 10.1016/j.clinph.2021.06.025
Agnese Zazio 1 , Carlo Miniussi 2 , Marta Bortoletto 1
Affiliation  

Objective

Communication-through-coherence proposes that the phase synchronization (PS) of neural oscillations between cortical areas supports neural communication. In this study, we exploited transcranial magnetic stimulation (TMS)-evoked potentials (TEPs) to test this hypothesis at the macroscale level, i.e., whether PS between cortical areas supports interarea communication. TEPs are electroencephalographic (EEG) responses time-locked to TMS pulses reflecting interarea communication, as they are generated by the transmission of neural activity from the stimulated area to connected regions. If interarea PS is important for communication, it should be associated with the TEP amplitude in the connected areas.

Methods

TMS was delivered over the left primary motor cortex (M1) of fourteen healthy volunteers, and 70-channel EEG was recorded. Early TEP components were source-localized to identify their generators, i.e., distant brain regions activated by M1 through effective connections. Next, linear regressions were used to test the relationship between the TEP amplitude and the pre-stimulus PS between the M1 and the connected regions in four frequency bands (range 4–45 Hz).

Results

Pre-stimulus interarea PS in the alpha-band was positively associated with the amplitude of early TEP components, namely, the N15 (ipsilateral supplementary motor area), P25 (contralateral M1) and P60 (ipsilateral parietal cortex).

Conclusions

Alpha-band PS predicts the response amplitude of the distant brain regions effectively connected to M1.

Significance

Our study supports the role of EEG-PS in interarea communication, as theorized by communication-through-coherence.



中文翻译:

阿尔法带皮质皮质相位同步与运动网络中的有效连接有关

客观的

通过相干通信提出皮层区域之间神经振荡的相位同步 (PS) 支持神经通信。在这项研究中,我们利用经颅磁刺激 (TMS) 诱发电位 (TEP) 在宏观水平上测试这一假设,即皮质区域之间的 PS 是否支持区域间通信。TEP 是与 TMS 脉冲时间锁定的脑电图 (EEG) 响应,反映区域间通信,因为它们是由神经活动从受刺激区域传输到连接区域产生的。如果区域间 PS 对通信很重要,它应该与连接区域中的 TEP 幅度相关联。

方法

TMS 在 14 名健康志愿者的左侧初级运动皮层 (M1) 上传递,并记录了 70 通道 EEG。早期的 TEP 组件被源定位以识别它们的发生器,即通过有效连接由 M1 激活的远处大脑区域。接下来,使用线性回归来测试 TEP 幅度与 M1 和四个频段(范围 4-45 Hz)中连接区域之间的预刺激 PS 之间的关系。

结果

α 波段中的预刺激区间 PS 与早期 TEP 成分的振幅正相关,即 N15(同侧补充运动区)、P25(对侧 M1)和 P60(同侧顶叶皮层)。

结论

Alpha 波段 PS 预测与 M1 有效连接的远处大脑区域的响应幅度。

意义

我们的研究支持 EEG-PS 在区域间通信中的作用,正如通信通过连贯性所提出的理论。

更新日期:2021-08-26
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