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Three New C19-Diterpenoid Alkaloids from Aconitum novoluridum
Chemical & Pharmaceutical Bulletin ( IF 1.7 ) Pub Date : 2021-08-01 , DOI: 10.1248/cpb.c21-00262
Jing Lu 1 , Jin-Bu Xu 1 , Xiaohuan Li 1 , Xian-Li Zhou 1 , Chungu Zhang 1 , Feng Gao 1
Affiliation  

Three new aconitine-type C19-diterpenoid alkaloid namely novolunines A (1), B (2), and C (3), along with fifteen known diterpenoid alkaloids were isolated from the roots of Aconitum novoluridum, whose phytochemical investigations have never been reported before. The structures of three new alkaloids were established on the basis of spectra data (high-resolution electrospray ionization (HR-ESI)-MS, IR, one dimensional (1D)- and 2D-NMR). Noteworthily, novolunines A (1) and B (2) are two diterpenoid alkaloids bearing conformational isomerism. In addition, the diterpenoid alkaloids 13 did not show any anti-acetylcholinesterase (AChE) or anti-inflammatory activities.

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中文翻译:

新乌头中三种新的 C19-二萜生物碱

三种新的乌头碱型 C 19 -二萜生物碱,即线型 A ( 1 )、B ( 2 ) 和 C ( 3 ),以及十五种已知的二萜生物碱从乌头的根中分离出来,其植物化学研究从未报道过前。三种新生物碱的结构是根据光谱数据(高分辨率电喷雾电离 (HR-ESI)-MS、IR、一维 (1D)-和 2D-​​NMR)建立的。值得注意的是,线型苯酚 A ( 1 ) 和 B ( 2 ) 是两种具有构象异构现象的二萜生物碱。此外,二萜生物碱13 未显示任何抗乙酰胆碱酯酶 (AChE) 或抗炎活性。

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更新日期:2021-08-01
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