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The onset of ulcerative colitis upon Helicobacter pylori eradication in a 72-year-old woman: report of a rare case with a 3-year follow-up
BMC Gastroenterology ( IF 2.4 ) Pub Date : 2021-07-31 , DOI: 10.1186/s12876-021-01876-5
J Homolak 1 , M Nikolić 2, 3 , D Potoč 3 , M Živković 2 , D Bakula 2 , I Budimir 2, 4 , I Pavić 5 , D Hrabar 2, 4 , N Ljubičić 2, 3, 4 , D Vražić 6
Affiliation  

Epidemiological studies suggest an inverse association between H. pylori infection/exposure and inflammatory bowel disease prevalence/incidence, however, there are no reports of individual patients who developed a "non-transient” ulcerative colitis (UC) following H. pylori eradication. We report a case of a 72-year-old female with an elderly-onset UC developed upon H. pylori eradication and a 3-year follow-up of the progression to steroid-dependent colitis complicated with enteropathic arthritis and final containment of the disease with golimumab. In our patient, H. pylori eradication was associated with the development of pancolitis that evolved into clinically, endoscopically, and pathohistologically confirmed UC. The case of our patient provides a unique clinical context for a growing body of literature suggesting molecular mechanisms involved in the interaction of genes, environment, and microbiota to be of critical importance in the etiopathogenesis of UC, and thus, provides a valuable set of complementary translational information for preclinical and epidemiological research on the topic.

中文翻译:

一位 72 岁女性根除幽门螺杆菌后溃疡性结肠炎的发作:1 例罕见病例的 3 年随访报告

流行病学研究表明,幽门螺杆菌感染/暴露与炎症性肠病患病率/发病率呈负相关,但是,没有关于在根除幽门螺杆菌后发生“非暂时性”溃疡性结肠炎 (UC) 的个别患者的报告。我们报告一例 72 岁女性,在根除幽门螺杆菌后发生老年性 UC,并对其进展为类固醇依赖性结肠炎并发肠病性关节炎进行了 3 年的随访,并最终控制了该疾病golimumab. 在我们的患者中,幽门螺杆菌的根除与全结肠炎的发展有关,后者在临床、内窥镜和病理组织学上证实为 UC。我们患者的病例为越来越多的文献提供了独特的临床背景,这些文献表明基因、环境和微生物群相互作用的分子机制在 UC 的发病机制中至关重要,因此,提供了一套有价值的补充有关该主题的临床前和流行病学研究的转化信息。
更新日期:2021-08-01
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