Dietary yeast cell wall products (YCW) are recognized as a feed additive due to multifunctional benefits by the biological response modulators. Thus, this study was conducted to verify a potential advantage of YCW for improving growth performance, nutrient digestibility, immune responses, and intestinal health and microbiota of weaned pigs. A total of 112 weaned pigs (7.99 ± 1.10 kg of body weight; 28 days old) were arbitrarily allocated to two experimental treatments with eight pigs (four barrows and four gilts) per pen and seven replicate pens per treatment in a completely randomized block design (block = BW and sex): (1) a basal diet based on corn and soybean meal (CON) and (2) CON + 0.05% YCW. The experimental period was for 4 weeks. There were no differences in final body weight, average daily feed intake, and gain-to-feed ratio between dietary treatments. In contrast, pigs fed YCW had higher average daily gain (p = 0.088) and apparent ileal digestibility of DM (p < 0.05) and energy (p = 0.052) and lower diarrhea frequency (p = 0.083) than those fed control diet (CON). Pigs fed YCW also had a higher (p < 0.05) ratio between villus height and crypt depth, villus width and area, and goblet cell counts in the duodenum and/or jejunum than those fed CON. Dietary YCW decreased (p < 0.05) serum TNF-α and IL–1β of weaned pigs on day 7 and 14, respectively, compared with CON. Furthermore, pigs fed YCW had higher (p < 0.05) ileal gene expression of claudin family, occludin, MUC1, INF-γ, and IL-6 and lower (p < 0.05) that of TNF-α than those fed CON. Lastly, there were no differences in the relative abundance of bacteria at the phylum level between CON and YCW. However, dietary YCW increased (p < 0.05) the relative abundance of genera Prevotella and Roseburia compared with CON. This study provided that dietary YCW improved growth rate, nutritional digestibility, and intestinal health and modified immune responses and intestinal microbiota of weaned pigs.

中文翻译：

---

日粮酵母细胞壁通过增强肠道健康和抗炎免疫反应来改善断奶仔猪的生长性能和预防腹泻

由于生物反应调节剂的多功能优势，日粮酵母细胞壁产品 (YCW) 被公认为饲料添加剂。因此，本研究旨在验证 YCW 在改善断奶仔猪生长性能、营养消化率、免疫反应以及肠道健康和微生物群方面的潜在优势。总共 112 头断奶猪（7.99 ± 1.10 kg 体重；28 日龄）被任意分配到两个实验处理中，每栏 8 头猪（4 头公猪和 4 头小母猪），每个处理在完全随机区组设计中重复 7 个栏（块 = BW 和性别）：(1) 基于玉米和豆粕 (CON) 的基础日粮和 (2) CON + 0.05% YCW。实验时间为4周。最终体重、平均每日采食量、和日粮处理之间的增重比。相比之下，喂食 YCW 的猪平均日增重更高（p = 0.088) 和 DM 的表观回肠消化率 ( p < 0.05) 和能量 ( p = 0.052) 以及比喂食对照饮食 (CON) 的腹泻频率更低 ( p = 0.083)。与饲喂 CON 的猪相比，饲喂 YCW 的猪的绒毛高度和隐窝深度、绒毛宽度和面积以及十二指肠和/或空肠中的杯状细胞计数之间的比率也更高（p < 0.05）。与 CON 相比，日粮 YCW分别在第 7 天和第 14 天降低（p < 0.05）断奶猪的血清 TNF-α 和 IL-1β。此外，饲喂 YCW 的猪具有更高 ( p < 0.05) 回肠基因表达的 claudin 家族、occludin、MUC1、INF-γ 和 IL-6 以及更低 ( p< 0.05) TNF-α 与 CON 相比。最后，CON 和 YCW 在门水平上的细菌相对丰度没有差异。然而，膳食YCW增加（p <0.05）属的相对丰度普雷沃和罗斯氏与CON相比。本研究表明，日粮 YCW 提高了断奶仔猪的生长速度、营养消化率和肠道健康，并改变了免疫反应和肠道微生物群。