With the increased risk of wound infection caused by pathogenic bacteria, silver nanoparticles have been considered as potential antibacterial nanosystem. However, the challenge of size control and agglomeration of silver nanoparticles need to be considered. Herein, the application of flower-like silver nanoparticles (Ag NPs) anchored Fe₃O₄@SiO₂@MnO₂ hybrids (Ag/FSM) in the control of pathogenic bacteria and promotion of wound healing were reported. TEM results indicated the ultrafine Ag NPs were uniformly dispersed onto the surface of FSM. In vitro experimental results showed the Minimum inhibitory concentration (MIC) of Ag/FSM against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) were 60 and 100$\mu$g mL⁻¹, respectively. Furthermore, in vivo investigation in mice demonstrated that the hybrids showed low toxicity and effectively promoted wound healing caused by the infection of E. coli. In summary, the results supported the possibility that Ag/FSM could be considered as an antibacterial agent with potential for the treatment of bacterial infections.

随着病原菌引起伤口感染的风险增加，银纳米颗粒被认为是潜在的抗菌纳米系统。然而，需要考虑银纳米粒子的尺寸控制和团聚的挑战。本文报道了花状银纳米粒子（Ag NPs）锚定 Fe ₃ O ₄ @SiO ₂ @MnO ₂杂化物（Ag/FSM）在控制病原菌和促进伤口愈合中的应用。TEM 结果表明超细 Ag NPs 均匀分散在 FSM 表面。体外实验结果表明，Ag/FSM 对大肠杆菌（E.coli）和金黄色葡萄球菌( S. aureus ) 分别为 60 和 100$\mu$g mL ^-1，分别。此外，小鼠体内研究表明，杂种表现出低毒性并有效促进由大肠杆菌感染引起的伤口愈合。总之，结果支持了 Ag/FSM 可被视为具有治疗细菌感染潜力的抗菌剂的可能性。