The asymmetric synthesis of enantiopure pyrrolidines is reported via a streamlined strategy relying on two sequential C−H functionalizations of simple hydrocarbons. The first step is a regio- and stereoselective catalytic nitrene C−H insertion. Then, a subsequent diastereoselective cyclization involving a 1,5-hydrogen atom transfer (HAT) from a N-centered radical leads to the formation of pyrrolidines that can then be converted to their free NH-derivatives.

中文翻译：

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通过碳氢化合物的 C(sp3)-H 胺化不对称合成对映体纯吡咯烷

对映体纯吡咯烷的不对称合成是通过依赖于简单烃的两个连续 CH 官能化的简化策略报道的。第一步是区域选择性和立体选择性催化氮烯 CH 插入。然后，随后的非对映选择性环化反应涉及来自 N 中心自由基的 1,5-氢原子转移 (HAT)，导致形成吡咯烷，然后可以将其转化为游离的 NH 衍生物。