A successful pregnancy is a complex and unique process comprised of discrete events, including embryo implantation, placentation, and parturition. To maintain the balance between maternal-fetal immune tolerance and resistance to infections, the maternal immune system must have a high degree of stage-dependent plasticity throughout the period of pregnancy. Innate immunity is the frontline force for the establishment of early anti-infection and tolerance mechanisms in mammals. Belonging to the innate immune system, a subset of T cells called γδT cells (based on γδT cell receptors) are the main participants in immune surveillance and immune defense. Unlike traditional αβT cells, γδT cells are regarded as a bridge between innate immunity and acquired immunity. In this review, we summarize current knowledge on the functional plasticity of γδT cells during pregnancy. Furthermore, we discuss the roles of γδT cells in pathological pregnancies.

中文翻译：

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γδT 细胞在妊娠和妊娠相关并发症中的作用

成功怀孕是一个复杂而独特的过程，由离散事件组成，包括胚胎植入、胎盘形成和分娩。为了维持母胎免疫耐受性和抗感染性之间的平衡，母体免疫系统必须在整个怀孕期间具有高度的阶段依赖性可塑性。先天免疫是建立哺乳动物早期抗感染和耐受机制的前线力量。属于先天免疫系统，称为γδT细胞（基于γδT细胞受体）的T细胞亚群是免疫监视和免疫防御的主要参与者。与传统的αβT细胞不同，γδT细胞被认为是先天免疫和获得性免疫之间的桥梁。在这次审查中，我们总结了当前关于 γδT 细胞在怀孕期间的功能可塑性的知识。此外，我们讨论了 γδT 细胞在病理性妊娠中的作用。