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Sensitivity enhancement in rGO/Mn3O4 hybrid nanocomposites: A modified glassy carbon electrode for the simultaneous detection of dopamine and uric acid
Synthetic Metals ( IF 4.4 ) Pub Date : 2021-07-30 , DOI: 10.1016/j.synthmet.2021.116859
G. Vinodhkumar 1 , Sujin P. Jose 2 , S. Lokeswarareddy 3 , C. Sekar 3 , I. Vetha Potheher 4 , A. Cyrac Peter 1
Affiliation  

A high sensitive electrochemical sensor was designed for the real time detection of dopamine (DA) and uric acid (UA) by using the Nanocomposite (NC) of reduced graphene oxide nano-octahedral shaped Mn3O4 modified Glassy Carbon Electrode (rGO/Mn3O4/GCE). The effect of Mn3O4 on the electrochemical and physical properties of rGO/Mn3O4 NC by Mn3O4 contents was analyzed by varying the molar ratio of Mn precursor (1, 5 and 10 mM denoted as GM1:1, GM1:5 and GM1:10 respectively). Due to the unique morphology and physical properties originated from Mn3O4, GM1:10/GCE revealed enhanced electrochemical response in terms of large peak potential separation, high selectivity and sensitivity. The GM1:10/GCE displayed a distinct SWV response to DA and UA for 1–600 μM at lowest detection limit of 1.42 μM and 0.76 μM. Additionally, anti-interference property of the designed sensor against electroactive molecules is found to be excellent stability and good reproducibility. Finally, it was make use for the detection of DA and UA in the pharmaceutical compound and physiological residue.



中文翻译:

rGO/Mn3O4 杂化纳米复合材料的灵敏度增强:一种用于同时检测多巴胺和尿酸的改良玻碳电极

使用还原氧化石墨烯纳米八面体形 Mn 3 O 4改性玻碳电极(rGO/Mn 3 O 4 /GCE)。Mn的效果3 ö 4上RGO的电化学性能和物理性能/ Mn为3 ö 4的Mn NC 3项ö 4分析内容通过改变锰的前体(1,5的摩尔比和10mM表示为GM 1:1 , 通用1:5和通用1:10分别)。由于源自 Mn 3 O 4的独特形态和物理性质,GM 1:10 /GCE 在大峰电位分离、高选择性和灵敏度方面显示出增强的电化学响应。GM 1:10 /GCE 在 1.42 μM 和 0.76 μM 的最低检测限下对 1–600 μM 的 DA 和 UA 显示出明显的 SWV 响应。此外,发现设计的传感器对电活性分子的抗干扰特性具有出色的稳定性和良好的再现性。最后用于药物化合物中DA和UA的检测以及生理残留的检测。

更新日期:2021-08-01
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