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Curcumin induced G2/M cycle arrest in SK-N-SH neuroblastoma cells through the ROS-mediated p53 signaling pathway
Journal of Food Biochemistry ( IF 4 ) Pub Date : 2021-07-31 , DOI: 10.1111/jfbc.13888
Zijie Ye 1 , Danyang Chen 2 , Ruilin Zheng 2 , Haiyang Chen 2 , Tiantian Xu 2 , Changbing Wang 2 , Shibo Zhu 1 , Xiaofeng Gao 1 , Jin Zhang 1 , Dian Li 1 , Yueyin Pang 3 , Bing Zhu 2 , Yinghua Li 2, 4 , Wei Jia 1
Affiliation  

Neuroblastoma (NB) is a solid tumor in the nervous system and has a high mortality rate in children. Curcumin has well-characterized anticancer properties, while there is no effective method in clinical treatment. MTT assays revealed that curcumin dramatically inhibited the proliferation of SK-N-SH cells. Compared with the control group, curcumin markedly restrained the migration of SK-N-SH cells. Curcumin induced SK-N-SH cell apoptosis by G2/M cycle arrest and activated caspase-3 activity. Furthermore, curcumin promoted the overproduction of intracellular ROS and apoptosis induced by activating p53 and Bcl-2 signal pathways. This finding demonstrated the application of curcumin is an effective strategy for the therapeutics of NB

中文翻译:

姜黄素通过 ROS 介导的 p53 信号通路诱导 SK-N-SH 神经母细胞瘤细胞的 G2/M 周期停滞

神经母细胞瘤(NB)是神经系统的实体瘤,在儿童中死亡率很高。姜黄素具有很好的抗癌特性,但临床治疗尚无有效方法。MTT 分析显示姜黄素显着抑制 SK-N-SH 细胞的增殖。与对照组相比,姜黄素显着抑制了SK-N-SH细胞的迁移。姜黄素通过 G2/M 周期阻滞和激活 caspase-3 活性诱导 SK-N-SH 细胞凋亡。此外,姜黄素促进细胞内 ROS 的过度产生和激活 p53 和 Bcl-2 信号通路诱导的细胞凋亡。这一发现表明姜黄素的应用是治疗 NB 的有效策略
更新日期:2021-09-06
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