Ulcerative colitis (UC), a subcategory of inflammatory bowel diseases, affects more than 2 million people globally. This study sought to investigate the curative ability of aqueous leaf extract of Telfairia occidentalis (ATO) on dextran sodium sulfate (DSS)-mediated colitis in rats. UC was induced by 5% of DSS in drinking water, and the curative ability of ATO was assessed at 200 mg/kg by oral administration for 10 days. The effect of ATO was deduced on anti-inflammatory, preclinical features [disease activity index (DAI)], redox assays, and alterations both microscopic and macroscopic of the colonic mucosa. DSS mediated inflammation in colons of rats with a significant increase in nitric oxide, myeloperoxidase, IL-1β, IL-6, and TNF-α levels compared with a control group. Lipid peroxidation was also induced following exposure of rats to DSS. There is a marked decrease in antioxidant enzymes activities in DSS group. However, treatment with ATO markedly inhibited the colonic inflammation by reversing the elevated levels of inflammatory markers. Furthermore, ATO suppressed the lipid peroxidation chain reaction by reducing the level of malondialdehyde and hydrogen peroxide. ATO attenuates DSS-induced oxidative stress by increase the level of GSH and enhancing the activities of the cytoprotective enzymes (catalase, glutathione-S-transferase, and superoxide dismutase). Taken together, ATO reduced DAI score, inhibited inflammation, suppressed lipid peroxidation, attenuated oxidative stress, and enhanced the antioxidant enzymes activities. These therapeutic effects of ATO might be due to its phytochemicals as showed in gas chromatography-mass spectroscopy results. The findings of this study indicate that aqueous leaf extract of T. occidentalis has could be a drug candidate for the treatment of UC.

中文翻译：

---

Telfairia occidentalis 通过抑制氧化应激、脂质过氧化和炎症减轻大鼠葡聚糖硫酸钠诱导的溃疡性结肠炎

溃疡性结肠炎 (UC) 是炎症性肠病的一个亚类，影响全球超过 200 万人。本研究旨在探讨西洋蜈蚣水叶提取物的治疗能力。(ATO) 对右旋糖酐硫酸钠 (DSS) 介导的大鼠结肠炎的影响。UC 由饮用水中 5% 的 DSS 诱发，以 200 mg/kg 口服给药 10 天评估 ATO 的治愈能力。推断 ATO 对抗炎、临床前特征 [疾病活动指数 (DAI)]、氧化还原测定以及结肠黏膜的微观和宏观改变的影响。与对照组相比，DSS 介导大鼠结肠炎症，一氧化氮、髓过氧化物酶、IL-1β、IL-6 和 TNF-α 水平显着增加。大鼠暴露于 DSS 后也诱导脂质过氧化。DSS组抗氧化酶活性明显降低。然而，ATO 治疗通过逆转炎症标志物水平升高显着抑制结肠炎症。此外，ATO 通过降低丙二醛和过氧化氢的水平来抑制脂质过氧化链反应。ATO 通过增加 GSH 水平和增强细胞保护酶（过氧化氢酶、谷胱甘肽-S-转移酶和超氧化物歧化酶）的活性来减弱 DSS 诱导的氧化应激。总之，ATO 降低了 DAI 评分，抑制了炎症，抑制了脂质过氧化，减轻了氧化应激，并增强了抗氧化酶的活性。ATO 的这些治疗作用可能是由于其植物化学物质，如气相色谱 - 质谱结果所示。这项研究的结果表明，水叶提取物 ATO 通过增加 GSH 水平和增强细胞保护酶（过氧化氢酶、谷胱甘肽-S-转移酶和超氧化物歧化酶）的活性来减弱 DSS 诱导的氧化应激。总之，ATO 降低了 DAI 评分，抑制了炎症，抑制了脂质过氧化，减轻了氧化应激，并增强了抗氧化酶的活性。ATO 的这些治疗作用可能是由于其植物化学物质，如气相色谱 - 质谱结果所示。这项研究的结果表明，水叶提取物 ATO 通过增加 GSH 水平和增强细胞保护酶（过氧化氢酶、谷胱甘肽-S-转移酶和超氧化物歧化酶）的活性来减弱 DSS 诱导的氧化应激。总之，ATO 降低了 DAI 评分，抑制了炎症，抑制了脂质过氧化，减轻了氧化应激，并增强了抗氧化酶的活性。ATO 的这些治疗作用可能是由于其植物化学物质，如气相色谱 - 质谱结果所示。这项研究的结果表明，水叶提取物 ATO 的这些治疗作用可能是由于其植物化学物质，如气相色谱 - 质谱结果所示。这项研究的结果表明，水叶提取物 ATO 的这些治疗作用可能是由于其植物化学物质，如气相色谱 - 质谱结果所示。这项研究的结果表明，水叶提取物T. occidentalis可能是治疗 UC 的候选药物。