Tumor cells are often exposed to hypoxia because of the lower oxygen supply deep inside the tumor tissues. However, tumor cells survive in these severe conditions by adapting to hypoxic stress through the induction of hypoxia-inducible factor 1 (HIF-1) signaling. HIF-1 activation is responsible for the expression of numerous HIF-1 target genes, which are related to cell survival, proliferation, angiogenesis, invasion, metastasis, cancer stemness, and metabolic reprogramming. Therefore, HIF-1 is expected to be a potential pharmacological target for cancer therapy. Small molecules derived from natural products (microbial origin, plant-derived, or marine organisms) have been shown to have unique chemical structures and biological activities, including HIF-1 inhibition. Several studies identified HIF-1 inhibitors from natural products. In this review, we summarize the current HIF-1 signaling inhibitors originating from natural products with a variety of modes of action, mainly focusing on microbial metabolites.

由于肿瘤组织深处的氧气供应较低，肿瘤细胞经常暴露在缺氧环境中。然而，肿瘤细胞通过诱导缺氧诱导因子 1 (HIF-1) 信号来适应缺氧应激，从而在这些严酷条件下存活。HIF-1 激活负责许多 HIF-1 靶基因的表达，这些基因与细胞存活、增殖、血管生成、侵袭、转移、癌症干性和代谢重编程有关。因此，HIF-1有望成为癌症治疗的潜在药理学靶点。来自天然产物（微生物来源、植物来源或海洋生物）的小分子已被证明具有独特的化学结构和生物活性，包括 HIF-1 抑制作用。几项研究从天然产物中发现了 HIF-1 抑制剂。在这篇评论中，