ABSTRACT

Objectives

To evaluate the association of Graves’ Ophthalmopathy (GO) with the meibomian glands and investigate the relation of ocular surface changes with meibomian gland parameters in patients with GO.

Methods

This prospective study included 44 eyes of 44 mild and moderate-to-severe GO patients and 38 eyes of 38 control subjects. After a complete ophthalmologic examination, patients were assessed according to the Clinical Activity Score (CAS). The area of meibomian gland loss and meibography score was evaluated using meibography (Sirius; CSO, Florence, Italy). Schirmer test, tear break-up time (TBUT) and Ocular Surface Disease Index (OSDI) scores were evaluated.

Results

Mean meibomian gland dropout area was 26.29 ± 1.58% in the GO group and 14.46 ± 1.52% in the healthy controls (p < .001). Mean meibography score in the GO group was 2.61 ± 0.15 while it was 1.32 ± 0.25 in the healthy controls (p < .001). Meibomian gland dropout area was positively correlated with CAS and OSDI questionnaire results (p = .015, r = 0.391; p < .001, r = 0.662, respectively) and negatively correlated with TBUT and Schirmer test scores (p < .001, r = −0.635; p = .003, r = −0.474, respectively). Meibography score was positively correlated with CAS and OSDI questionnaire results (p = .012, r = 0.383; p = .007, r = 0.419, respectively) and negatively correlated with TBUT and Schirmer test scores (p = .002, r = −0.467; p = .023, r = −0.359, respectively).

Conclusion

Meibomian glands are quantitatively decreased in patients with GO. The decrease of meibomian glands is correlated with objective and subjective dry eye findings. Dry eye treatment in GO patients should include meibomian gland deficiency as well.

中文翻译：

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轻度和中重度 Graves 眼病患者睑板腺丧失和眼表变化的评估

摘要

目标

评估 Graves 眼病 (GO) 与睑板腺的关系，并探讨 GO 患者眼表变化与睑板腺参数的关系。

方法

这项前瞻性研究包括 44 名轻度和中度至重度 GO 患者的 44 只眼和 38 名对照受试者的 38 只眼。在完成眼科检查后，根据临床活动评分（CAS）对患者进行评估。使用 meibography（Sirius；CSO，Florence，Italy）评估睑板腺损失的面积和 meibography 评分。评估 Schirmer 测试、泪液破裂时间 (TBUT) 和眼表疾病指数 (OSDI) 评分。

结果

GO 组的平均睑板腺脱落面积为 26.29 ± 1.58%，健康对照组为 14.46 ± 1.52% ( p  < .001)。GO 组的平均 meibography 得分为 2.61 ± 0.15，而健康对照组为 1.32 ± 0.25 ( p  < .001)。睑板腺脱落面积与 CAS 和 OSDI 问卷结果呈正相关（分别为p  = .015，r = 0.391；p  < .001，r = 0.662），与 TBUT 和 Schirmer 测试分数呈负相关（p  < .001，r = -0.635；p  = .003，r = -0.474）。Meibography 评分与 CAS 和 OSDI 问卷结果呈正相关（p  = .012，r = 0.383；p = .007, r = 0.419，分别与 TBUT 和 Schirmer 测试分数呈负相关（分别为p  = .002，r = -0.467；p  = .023，r = -0.359）。

结论

GO 患者的睑板腺数量减少。睑板腺的减少与客观和主观干眼症的发现有关。GO 患者的干眼症治疗也应包括睑板腺缺乏症。