Tumor microenvironment (TME) can serve as the 'soil' for the growth and survival of tumor cells and function synergically with tumor cells to mediate tumor progression and therapeutic resistance. Reactive oxygen species (ROS) is somewhat of a double‑edged sword for tumors. Accumulating evidence has reported that regulating ROS levels can serve an anti‑tumor role in the TME, including the promotion of cancer cell apoptosis, inhibition of angiogenesis, preventing immune escape, manipulating tumor metabolic reorganization and improving drug resistance. In the present review, the potential role of ROS in anti‑tumor therapy was summarized, including the possibility of directly or indirectly targeting the TME.

中文翻译：

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基于“种子和土壤”理论的活性氧在肿瘤中的作用：复杂的相互作用（综述）。

肿瘤微环境 (TME) 可以作为肿瘤细胞生长和存活的“土壤”，并与肿瘤细胞协同发挥作用，介导肿瘤进展和治疗抵抗。活性氧 (ROS) 在某种程度上对肿瘤来说是一把双刃剑。越来越多的证据表明，调节 ROS 水平可以在 TME 中发挥抗肿瘤作用，包括促进癌细胞凋亡、抑制血管生成、防止免疫逃逸、调控肿瘤代谢重组和提高耐药性。在本综述中，总结了 ROS 在抗肿瘤治疗中的潜在作用，包括直接或间接靶向 TME 的可能性。