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Exercise and Heat Stress: Inflammation and the Iron Regulatory Response
International Journal of Sport Nutrition and Exercise Metabolism ( IF 2.5 ) Pub Date : 2021-07-29 , DOI: 10.1123/ijsnem.2021-0080
Alannah K A McKay 1 , Rachel McCormick 2 , Nicolin Tee 1 , Peter Peeling 2, 3
Affiliation  

This study determined the impact of heat stress on postexercise inflammation and hepcidin levels. Twelve moderately trained males completed three, 60-min treadmill running sessions under different conditions: (a) COOL, 18 °C with speed maintained at 80% maximum heart rate; (b) HOTHR, 35 °C with speed maintained at 80% maximum heart rate; and (c) HOTPACE, 35 °C completed at the average running speed from the COOL trial. Venous blood samples were collected pre-, post-, and 3-hr postexercise and analyzed for serum ferritin, interleukin-6 (IL-6), and hepcidin concentrations. Average HR was highest during HOTPACE compared with HOTHR and COOL (p < .001). Running speed was slowest in HOTHR compared with COOL and HOTPACE (p < .001). The postexercise increase in IL-6 was greatest during HOTPACE (295%; p = .003). No differences in the IL-6 response immediately postexercise between COOL (115%) and HOTHR (116%) were evident (p = .992). No differences in hepcidin concentrations between the three trials were evident at 3 hr postexercise (p = .407). Findings from this study suggest the IL-6 response to exercise is greatest in hot compared with cool conditions when the absolute running speed was matched. No differences in IL-6 between hot and cool conditions were evident when HR was matched, suggesting the increased physiological strain induced from training at higher intensities in hot environments, rather than the heat per se, is likely responsible for this elevated response. Environmental temperature had no impact on hepcidin levels, indicating that exercising in hot conditions is unlikely to further impact transient alterations in iron regulation, beyond that expected in temperate conditions.



中文翻译:

运动和热应激:炎症和铁调节反应

这项研究确定了热应激对运动后炎症和铁调素水平的影响。12 名受过中等训练的男性在不同条件下完成了 3 次 60 分钟的跑步机跑步训练:(a) 凉爽,18 °C,速度保持在 80% 最大心率;(b) HOT HR,35 °C,速度保持在最大心率的 80%;(c) HOT PACE,35 °C 以 COOL 试验的平均跑步速度完成。在运动前、运动后和运动后 3 小时收集静脉血样本,并分析血清铁蛋白、白细胞介素 6 (IL-6) 和铁调素浓度。与 HOT HR和 COOL相比, HOT PACE期间的平均 HR 最高( p  < .001)。HOT HR中跑步速度最慢与 COOL 和 HOT PACE相比( p  < .001)。运动后 IL-6 的增加在 HOT PACE期间最大(295%;p  = .003)。COOL (115%) 和 HOT HR (116%) 在运动后立即产生的 IL-6 反应没有明显差异 ( p  = .992)。运动后 3 小时,三项试验的铁调素浓度没有明显差异(p = .407)。这项研究的结果表明,当绝对跑步速度匹配时,IL-6 对运动的反应在炎热条件下比凉爽条件下最大。当 HR 匹配时,热和冷条件之间的 IL-6 没有明显差异,这表明在热环境中以较高强度训练引起的生理应变增加,而不是热量本身,可能是导致这种升高的反应的原因。环境温度对铁调素水平没有影响,这表明在炎热条件下锻炼不太可能进一步影响铁调节的瞬时变化,超出温带条件下的预期。

更新日期:2021-07-29
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