The aim of present work is one-pot catalyst free green synthesis of tetrahydropyrimidne derivatives through Biginelli condensation under ultrasonic irradiation.

The chemical applications of ultrasound, "sonochemistry", has become an exciting new field of research during the past decade as it can increase reactivities by nearly a million fold. Owing to the increasing use of Green technology approach, due to its various merits over Classical methodology and as a need for sustainable Chemistry, this reaction has received renewed interest for preparing tetrahydropyrimidine (THPM) through Biginelii condensation in an environmentally thoughtful manner with improved yields.

The objective of the present study is focused on developing novel Ultrasound-Assisted catalyst free one-pot synthesis of tetrahydropyrimidne derivatives through Biginelli condensation We, herein describe a highly efficient catalyst free one-pot green synthesis of tetrahydropyrimidine derivatives using Biginelli protocol under ultrasonic irradiation at 50°C. All the products were characterized by comparing their physical and spectral data with those of authentic compounds reported in the literature.

A green and efficient ultrasound-assisted one-pot synthesis method for tetrahydro-yrimidine derivatives have been developed through Biginelli condensation. The technique affords up to 99% yield in only 5–20 minutes under mild heating. Each synthesized compounds were fully characterized through spectral techniques viz. IR, ¹H NMR, and Mass Spectroscopy.

A green and efficient ultrasound-assisted one-pot synthesis method for tetrahy-droyrimidine derivatives have been developed through Biginelli condensation. The present sonochemistry based green chemistry approach with no additional acid catalyst produces no waste, shows a significant enhancement in reaction rates under mild ultrasound irradiation in excellent yields and therefore represents a green and enviro-economic synthetic methodology for the Biginelli condensation in comparison to conventional heating/micro-wave irradiation.

本工作的目的是在超声波辐照下通过 Biginelli 缩合一锅法无催化剂绿色合成四氢嘧啶衍生物。

在过去十年中，超声波的化学应用“声化学”已成为一个令人兴奋的新研究领域，因为它可以将反应性提高近一百万倍。由于越来越多地使用绿色技术方法，由于其优于经典方法的各种优点以及对可持续化学的需求，该反应以环境周到的方式通过 Biginelii 缩合制备四氢嘧啶（THPM），并提高了产率，因此重新引起了人们的兴趣。

本研究的目的是开发新型超声辅助无催化剂四氢嘧啶衍生物通过 Biginelli 缩合一锅法合成我们在此描述了一种高效的无催化剂四氢嘧啶衍生物一锅绿色合成方法，在超声波照射下使用 Biginelli 协议50°C。通过将它们的物理和光谱数据与文献中报道的真实化合物的物理和光谱数据进行比较来表征所有产品。

通过Biginelli缩合，开发了一种绿色高效的超声辅助四氢嘧啶衍生物的一锅合成方法。该技术在温和加热下仅 5-20 分钟即可提供高达 99% 的产率。每种合成的化合物都通过光谱技术进行了充分表征。IR、¹ H NMR和质谱。

通过Biginelli缩合，开发了一种绿色高效的超声辅助四氢嘧啶衍生物的一锅合成方法。目前基于声化学的绿色化学方法不产生额外的酸催化剂，不会产生废物，在温和超声辐照下以优异的产率显着提高反应速率，因此与传统加热相比，代表了 Biginelli 缩合的绿色和环境经济合成方法/微波照射。