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The immunological and metabolic landscape in primary and metastatic liver cancer
Nature Reviews Cancer ( IF 78.5 ) Pub Date : 2021-07-29 , DOI: 10.1038/s41568-021-00383-9
Xin Li 1 , Pierluigi Ramadori 1 , Dominik Pfister 1 , Marco Seehawer 2, 3 , Lars Zender 2, 4, 5 , Mathias Heikenwalder 1
Affiliation  

The liver is the sixth most common site of primary cancer in humans, and generally arises in a background of cirrhosis and inflammation. Moreover, the liver is frequently colonized by metastases from cancers of other organs (particularly the colon) because of its anatomical location and organization, as well as its unique metabolic and immunosuppressive environment. In this Review, we discuss how the hepatic microenvironment adapts to pathologies characterized by chronic inflammation and metabolic alterations. We illustrate how these immunological or metabolic changes alter immunosurveillance and thus hinder or promote the development of primary liver cancer. In addition, we describe how inflammatory and metabolic niches affect the spreading of cancer metastases into or within the liver. Finally, we review the current therapeutic options in this context and the resulting challenges that must be surmounted.



中文翻译:

原发性和转移性肝癌的免疫学和代谢图谱

肝脏是人类第六大最常见的原发性癌症部位,通常出现在肝硬化和炎症的背景下。此外,由于其解剖位置和组织以及其独特的代谢和免疫抑制环境,肝脏经常被其他器官(特别是结肠)的癌症转移。在这篇综述中,我们讨论了肝脏微环境如何适应以慢性炎症和代谢改变为特征的病理。我们说明了这些免疫学或代谢变化如何改变免疫监视,从而阻碍或促进原发性肝癌的发展。此外,我们描述了炎症和代谢生态位如何影响癌症转移到肝脏或肝脏内的扩散。最后,

更新日期:2021-07-30
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