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Titanium dioxide particles from the diet: involvement in the genesis of inflammatory bowel diseases and colorectal cancer
Particle and Fibre Toxicology ( IF 10 ) Pub Date : 2021-07-30 , DOI: 10.1186/s12989-021-00421-2
Frédérick Barreau 1, 2 , Céline Tisseyre 3 , Sandrine Ménard 1, 2 , Audrey Ferrand 1, 2 , Marie Carriere 3
Affiliation  

The gastrointestinal tract is a complex interface between the external environment and the immune system. Its ability to control uptake across the mucosa and to protect the body from damage of harmful substances from the lumen is defined as the intestinal barrier function (IBF). The IBF involves four elements: the intestinal microbiota, the mucus layer, the epithelium and the immune system. Its dysfunction is linked with human diseases including inflammatory, metabolic, infectious, autoimmune and neurologic disorders. Most of these diseases are complex and involve genetic, psychological and environmental factors. Over the past 10 years, many genetic polymorphisms predisposing to inflammatory bowel disease (IBD) have been identified. Yet, it is now clear that they are insufficient to explain the onset of these chronic diseases. Although it has been evidenced that some environmental factors such as cigarette smoking or carbohydrate intake are associated with IBD, other environmental factors also present potential health risks such as ingestion of food additives introduced in the human diet, including those composed of mineral particles, by altering the four elements of the intestinal barrier function. The aim of this review is to provide a critical opinion on the potential of TiO2 particles, especially when used as a food additive, to alter the four elements of the intestinal barrier function, and consequently to evaluate if this additive would likely play a role in the development and/or exacerbation of IBD.

中文翻译:

饮食中的二氧化钛颗粒:参与炎症性肠病和结直肠癌的发生

胃肠道是外部环境和免疫系统之间的复杂界面。其控制跨粘膜吸收和保护身体免受来自管腔的有害物质损害的能力被定义为肠屏障功能(IBF)。IBF 涉及四个要素:肠道微生物群、粘液层、上皮和免疫系统。其功能障碍与人类疾病有关,包括炎症、代谢、感染、自身免疫和神经系统疾病。这些疾病大多是复杂的,涉及遗传、心理和环境因素。在过去的 10 年中,已经确定了许多易患炎症性肠病 (IBD) 的基因多态性。然而,现在很明显,它们不足以解释这些慢性疾病的发生。虽然已经证明一些环境因素,如吸烟或碳水化合物摄入量与 IBD 相关,但其他环境因素也存在潜在的健康风险,如摄入人类饮食中引入的食品添加剂,包括那些由矿物质颗粒组成的食品添加剂,通过改变肠道屏障功能的四大要素。本综述的目的是就 TiO2 颗粒(尤其是用作食品添加剂时)改变肠道屏障功能的四个要素的潜力提供批判性意见,并因此评估该添加剂是否可能在以下方面发挥作用IBD 的发展和/或恶化。其他环境因素也存在潜在的健康风险,例如通过改变肠道屏障功能的四个要素,摄入人类饮食中引入的食品添加剂,包括由矿物质颗粒组成的添加剂。本综述的目的是就 TiO2 颗粒(尤其是用作食品添加剂时)改变肠道屏障功能的四个要素的潜力提供批判性意见,并因此评估该添加剂是否可能在以下方面发挥作用IBD 的发展和/或恶化。其他环境因素也存在潜在的健康风险,例如通过改变肠道屏障功能的四个要素,摄入人类饮食中引入的食品添加剂,包括由矿物质颗粒组成的添加剂。本综述的目的是就 TiO2 颗粒(尤其是用作食品添加剂时)改变肠道屏障功能的四个要素的潜力提供批判性意见,并因此评估该添加剂是否可能在以下方面发挥作用IBD 的发展和/或恶化。
更新日期:2021-07-30
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