Abstract

Objectives

We aimed to gather and update the evidence on the impact of exercise on late-life depression.

Method

We conducted an umbrella review of meta-analyses of randomized controlled trials (RCTs) that assessed the effects of an exercise intervention for depression in older adults (e.g. 60+). Searches were conducted in Scopus, Web of Science, Embase, PubMed, BIREME, LILACS, SciELO, Cochrane Library for Systematic Reviews, and Opengray.eu. Methodological quality was assessed using A MeaSurement Tool to Assess Systematic Reviews (AMSTAR 2). Data analysis was performed with RStudio (version 4.0.2) and the generic inverse-variance method was used to pool the effect sizes from the included studies.

Results

Twelve meta-analyses of 97 RCTs were included. The AMSTAR 2 rating was considered critically low in five studies, low in six studies, and high in one study. The effect size expressed by the standardized mean difference (SMD) varied between studies from −0.90 (95% CI = −1.51; −0.28) to −0.14 (95% CI = −0.36; 0.07) in favor of the exercise intervention. Pooling of the effect sizes produced a statistically significant moderate effect in which exercise was associated with lower levels of depression and depressive symptoms (OR = 2.24, 95% CI 1.77; 2.84).

Conclusion

Our findings suggest that exercise produces a moderate improvement in depression and depressive symptoms in older patients. We recommend providing physical activity for older adults.

Key-points

We investigated the effects of exercise interventions for depression in older adults.

Supplemental data for this article can be accessed online at https://doi.org/10.1080/13607863.2021.1951660.

中文翻译：

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老年人抑郁症和抑郁症状的锻炼：系统评价和荟萃分析的综合评价

摘要

目标

我们旨在收集和更新有关运动对晚年抑郁症影响的证据。

方法

我们对评估运动干预对老年人（例如 60 岁以上）抑郁症的效果的随机对照试验 (RCT) 的荟萃分析进行了综合评价。在 Scopus、Web of Science、Embase、PubMed、BIREME、LILACS、SciELO、Cochrane 系统评价图书馆和 Opengray.eu 中进行了搜索。方法学质量使用 A MeaSurement Tool to Assess Systematic Reviews (AMSTAR 2) 进行评估。使用 RStudio（版本 4.0.2）进行数据分析，并使用通用逆方差方法从纳入研究中汇集效应量。

结果

纳入了 97 项 RCT 的 12 项荟萃分析。AMSTAR 2 评级在五项研究中被认为极低，在六项研究中被认为很低，在一项研究中被认为很高。由标准化平均差 (SMD) 表示的效应量在研究之间从 -0.90 (95% CI = -1.51; -0.28) 到 -0.14 (95% CI = -0.36; 0.07) 变化，有利于运动干预。合并效应量产生了具有统计学意义的中等效应，其中运动与较低水平的抑郁和抑郁症状相关（OR = 2.24, 95% CI 1.77; 2.84）。

结论

我们的研究结果表明，运动可以适度改善老年患者的抑郁和抑郁症状。我们建议为老年人提供体育锻炼。

关键点

我们调查了运动干预对老年人抑郁症的影响。

本文的补充数据可在线访问 https://doi.org/10.1080/13607863.2021.1951660。