Febrile seizures (FS) are one of the most common types of convulsive disorder of early childhood and they can be classified into simple and prolonged depending on the duration. Nowadays, simple FS have a good prognosis but there is controversy about the outcome of prolonged FS. In a previous work using an animal model of prolonged FS, we showed that hiperthermia-induced seizures (HIS) evoked fine motor coordination impairment and gait disturbances in adolescent rats in a process in which seemed to be involved modulation of the cerebellar adenosinergic system. The aim of the present work was to verify whether the effect was maintained in adulthood. To this end, neonatal rats (PD 12) were exposed to HIS and after 48 days (PD 60) they were assayed on balance beam and footprint tests. Animals were sacrificed 53 days after HIS and adenosine A₁ and A_2A receptor signalling pathways were studied in cerebellar plasma membranes by using radioligand binding assays and by measuring the activities of 5´-nucleotidase and adenylyl cyclase. Results obtained revealed that adult rats exposed to HIS showed gait disturbances and motor impairments. Besides, animals exposed to hyperthermic insult showed an increase in adenosine A_2A receptor functionality and 5´-nucleotidase activity. Surprisingly, the functionality of the adenosine A₁ receptor resulted significantly changed causing stimulation instead of inhibition of adenylate cyclase activity. These results showed that the effect of prolonged FS at the early age also persist in adulthood suggesting on must pay attention to FS in children.

热性惊厥 (FS) 是儿童早期最常见的惊厥类型之一，根据持续时间可分为单纯性惊厥和长期惊厥。如今，单纯性 FS 预后良好，但长期 FS 的结果存在争议。在先前使用长期 FS 动物模型的工作中，我们发现高温诱发的癫痫发作 (HIS) 在青春期大鼠中引起精细运动协调障碍和步态障碍，其过程似乎与小脑腺苷能系统的调节有关。目前工作的目的是验证这种效果是否在成年后保持不变。为此，将新生大鼠 (PD 12) 暴露于 HIS，并在 48 天后 (PD 60) 对它们进行平衡木和足迹测试。在 HIS 和腺苷 A 后 53 天处死动物通过使用放射性配体结合测定和测量 5´-核苷酸酶和腺苷酸环化酶的活性，研究了小脑质膜中的₁和 A _2A受体信号通路。获得的结果表明，暴露于 HIS 的成年大鼠表现出步态障碍和运动障碍。此外，暴露于高温损伤的动物显示腺苷 A _2A受体功能和 5´-核苷酸酶活性增加。令人惊讶的是，腺苷 A ₁受体的功能性导致显着改变，导致刺激而不是抑制腺苷酸环化酶活性。这些结果表明，早期FS延长的影响在成年期也持续存在，提示必须注意儿童FS。