Studying the nonlinear synchronization of electroencephalogram (EEG) in type 2 diabetic mellitus (T2DM) to find the EEG characteristics related to cognitive impairment is beneficial to the early prevention and diagnosis of mild cognitive impairment. Correlation between probabilities of recurrence (CPR) is a nonlinear phase synchronization method based on recurrence and recurrence probability, which had shown its superiority in detecting epilepsy. In this study, CPR method was used for the first time to analyze the synchronization of eye-closed resting EEG signals with T2DM. The 27 participants were divided into amnesic mild cognitive impairment (aMCI) group (17 case) and control group (10 cases with age and education matched). The CPR values in two groups were statistically analyzed by Mann-Whitney U test, and the correlation between EEG synchronization and cognitive function was studied by Spearman’s correlation. The results showed that aMCI group had lower CPR values at each electrode pair than control group, and two groups had decreased CPR values with the increase of the spatial distance of the electrode pair in inter hemispheric. The CPR values were significantly different in frontal, parietal and temporal regions in intra hemispheric between two groups. The CPR values of C3-F7, F4-C4 and FP2-T6 were significantly positively correlated with the MOCA values. This study showed that the synchronization values of EEG signals obtained by the CPR method were significantly different between aMCI and control group, and they were the EEG characteristics associated with cognitive impairment in T2DM.

研究2型糖尿病（T2DM）脑电图（EEG）的非线性同步，寻找与认知障碍相关的脑电图特征，有利于轻度认知障碍的早期预防和诊断。复发概率之间的相关性（CPR）是一种基于复发和复发概率的非线性相位同步方法，在检测癫痫方面已显示出其优越性。本研究首次采用CPR方法分析闭眼静息脑电信号与T2DM的同步性。27 名参与者被分为健忘性轻度认知障碍（aMCI）组（17 例）和对照组（10 例，年龄和教育程度相匹配）。两组CPR值采用Mann-Whitney U检验进行统计分析，并通过Spearman相关性研究脑电同​​步与认知功能的相关性。结果显示，aMCI组各电极对的CPR值均低于对照组，两组CPR值随半球间电极对空间距离的增加而降低。两组间半球内额叶、顶叶和颞区的CPR值存在显着差异。C3-F7、F4-C4和FP2-T6的CPR值与MOCA值呈显着正相关。本研究表明，通过CPR方法获得的脑电信号同步值在aMCI组与对照组之间存在显着差异，是与T2DM认知障碍相关的脑电特征。