ABSTRACT

Purpose

This study aimed to investigate the effect of nimodipine on peripapillary and macular capillary vessel density (VD) in patients with normal-tension glaucoma (NTG) using optical coherence tomography angiography (OCTA).

Methods

Sixty mg nimodipine was administered to 20 enrolled NTG patients for 3 months. Patients were treated with glaucoma medication simultaneously. The macular and peripapillary VD were measured automatically by OCTA at baseline, 1.5 h after administering nimodipine, and after 3 months of administering the drug. The retinal nerve fibre layer (RNFL), ganglion cell complex thickness, visual field (VF) testing, intraocular pressure (IOP), blood pressure and pulse rate in each subject were assessed during each follow-up.

Results

Compared with the baseline, the parafovea VD was higher (50.89 ± 4.26 versus 46.80 ± 5.40, P = .044) 1.5 h after administration of nimodipine. After administration of nimodipine for 3 months, the parafovea VD was obviously increased (51.14 ± 5.68 versus 46.80 ± 5.40, P = .039), while IOP, systolic blood pressure, mean arterial pressure and mean ocular perfusion pressure were decreased compared to baseline (all P < .05). No significant differences were found between the radial peripapillary capillary and disc VD. The parafovea VD was positively correlated with the administration of nimodipine (β = 0.39, P = .004), RNFL thickness (β = 0.49, P = .022), and VF mean deviation (β = 0.4, P = .040) in the multivariate analysis.

Conclusions

Nimodipine effectively increased superficial macular capillary VD, but did not affect peripapillary capillary VD in patients with NTG. This finding indicates that patients with NTG may benefit from the administration of nimodipine.

中文翻译：

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尼莫地平对正常眼压性青光眼患者黄斑和视盘毛细血管密度的影响光学相干断层扫描血管造影

摘要

目的

本研究旨在使用光学相干断层扫描血管造影（OCTA）研究尼莫地平对正常眼压青光眼（NTG）患者的视盘周围和黄斑毛细血管密度（VD）的影响。

方法

20 名登记的 NTG 患者服用 60 mg 尼莫地平，为期 3 个月。患者同时接受青光眼药物治疗。OCTA 在基线、给药尼莫地平后 1.5 小时和给药 3 个月后自动测量黄斑和视乳头周围 VD。在每次随访期间评估每位受试者的视网膜神经纤维层（RNFL）、神经节细胞复合体厚度、视野（VF）测试、眼压（IOP）、血压和脉搏率。

结果

与基线相比，尼莫地平给药 1.5 小时后，中心凹 VD 较高（50.89 ± 4.26 对 46.80 ± 5.40，P = .044）。服用尼莫地平 3 个月后，中央凹旁 VD 明显增加（51.14 ± 5.68 vs 46.80 ± 5.40，P = .039），而眼压、收缩压、平均动脉压和平均眼灌注压与基线相比降低（所有P < .05）。在径向毛细血管和椎间盘 VD 之间没有发现显着差异。中央凹 VD 与尼莫地平 (β = 0.39, P = .004)、RNFL 厚度 (β = 0.49, P = .022) 和 VF 平均偏差 (β = 0.4, P= .040) 在多变量分析中。

结论

尼莫地平有效增加浅表黄斑毛细血管 VD，但不影响 NTG 患者的视盘周围毛细血管 VD。这一发现表明 NTG 患者可能受益于尼莫地平的给药。