Several valuable biologically active molecules can be obtained through C–H activation processes. However, the use of expensive and not readily accessible catalysts complicates the process of pharmacological application of these compounds. A plausible way to overcome this issue is developing and using cheaper, more accessible, and equally effective catalysts. First-row transition (3d) metals have shown to be important catalysts in this matter. This review summarizes the use of 3d metal catalysts in C–H activation processes to obtain potentially (or proved) biologically active compounds.

中文翻译：

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关于 3d 金属在 C-H 活化中对生物活性化合物的应用：合成银弹的关键步骤

通过 C-H 活化过程可以获得几种有价值的生物活性分子。然而，使用昂贵且不易获得的催化剂使这些化合物的药理学应用过程复杂化。克服这个问题的一个可行方法是开发和使用更便宜、更容易获得且同样有效的催化剂。第一排过渡 (3d) 金属已被证明是这方面的重要催化剂。这篇综述总结了 3d 金属催化剂在 C-H 活化过程中的使用，以获得潜在（或证明）的生物活性化合物。