Abstract

OBJECTIVES

The purpose of this study was to determine the expression of PD-L1 in oesophageal squamous cell carcinoma (OSCC) and the prognostic factors.

METHODS

PD-L1 expression was investigated by immunohistochemical staining of resected specimens from 50 OSCC patients who were randomly selected from 104 patients with complete follow-up data. The relationships among PD-L1 expression, clinicopathological factors and prognosis were assessed by statistical analysis.

RESULTS

The expression of PD-L1 was positive in 27 (54%, positive cells’ proportion > 25%) and negative in 23 (46%, positive cells proportion ≤25%) of 50 cases, and PD-L1 expression was negative in all pericarcinomatous tissues (P > 0.05). The 5-year survival rate of patients with PD-L1-positive expression was 22.2% (6 of 27), which was less than that of patients with PD-L1-negative expression (47.8%; 11 of 23) (P < 0.05). The results showed significant differences in the depth of tumour invasion, lymph node status, postoperative pathological stage and PD-L1 expression (P < 0.05). Multivariable analysis showed that PD-L1 expression was an independent prognostic factor for survival.

CONCLUSIONS

The depth of tumour invasion, lymph node status, postoperative pathological stage and PD-L1 expression are important factors affecting the prognosis of patients with thoracic OSCC; in particular, high PD-L1 expression was a significant independent poor prognostic factor in thoracic OSCC patients.

中文翻译：

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胸段食管鳞状细胞癌中PD-L1表达的预后因素分析

摘要

目标

本研究的目的是确定 PD-L1 在食管鳞状细胞癌 (OSCC) 中的表达及其预后因素。

方法

通过对 50 名 OSCC 患者的切除标本进行免疫组织化学染色研究 PD-L1 表达，这些患者从 104 名具有完整随访数据的患者中随机选择。通过统计分析评估PD-L1表达、临床病理因素和预后之间的关系。

结果

50例PD-L1表达阳性27例（54%，阳性细胞比例>25%），阴性23例（46%，阳性细胞比例≤25%），PD-L1表达均为阴性癌周组织（P  > 0.05）。PD-L1 阳性表达患者的 5 年生存率为 22.2%（27 人中有 6 人），低于 PD-L1 表达阴性患者（47.8%；23 人中有 11 人）（P  < 0.05 ） ）。结果显示，肿瘤浸润深度、淋巴结状态、术后病理分期和PD-L1表达差异有统计学意义（P  < 0.05）。多变量分析表明，PD-L1 表达是生存的独立预后因素。

结论

肿瘤浸润深度、淋巴结状态、术后病理分期和PD-L1表达是影响胸部OSCC患者预后的重要因素；特别是，高 PD-L1 表达是胸部 OSCC 患者的重要独立不良预后因素。