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Longitudinal associations between C-reactive protein and cognitive performance in normative cognitive ageing and dementia
Age and Ageing ( IF 6.7 ) Pub Date : 2021-06-22 , DOI: 10.1093/ageing/afab152
Nathan A Lewis 1 , Jamie E Knight 1
Affiliation  

Background systemic inflammation appears to play an important role in the pathogenesis and expression of Alzheimer’s disease and other dementias. Previous research has found that elevated levels of serum C-reactive protein (CRP) is associated with poorer cognitive functioning and increased risk for dementia. However, most studies are limited by single CRP measurements, which fail to capture long-term inflammatory exposures or dynamic changes in inflammation and cognition which may occur across repeated measurements. Methods using data from 3,563 older adults aged 65–101 from the Health and Retirement Study, we examined bivariate changes in CRP and cognition measured repeatedly over a 10-year follow-up. Bivariate multilevel models estimated the effect of time-varying CRP on cognition among cognitively healthy older adults and in a subset of 427 participants who reported incident dementia onset during the follow-up period. Results in cognitively healthy participants, CRP was associated with lower level of cognitive functioning, but not rate of change over time. This effect was significant in participants under 80 years of age (b = −0.09, standard error (SE) = 0.05, P = 0.04), but not in older participants. In participants with incident dementia, those with higher CRP experienced smaller rates of cognitive decline, leading up to dementia diagnosis. Conclusions elevated levels of CRP predict poorer cognition and increased dementia risk in cognitively healthy adults under the age of 80. Conversely, increased CRP may confer protective effects on cognition in the prodromal stage of dementia.

中文翻译:

C反应蛋白与正常认知老化和痴呆的认知表现之间的纵向关联

背景全身性炎症似乎在阿尔茨海默病和其他痴呆的发病机制和表达中起重要作用。先前的研究发现,血清 C 反应蛋白 (CRP) 水平升高与认知功能较差和痴呆风险增加有关。然而,大多数研究受到单一 CRP 测量的限制,这些测量未能捕捉到长期炎症暴露或炎症和认知的动态变化,这些变化可能在重复测量中发生。方法使用来自健康和退休研究的 3,563 名 65-101 岁老年人的数据,我们检查了在 10 年的随访中反复测量的 CRP 和认知的双变量变化。双变量多水平模型估计了随时间变化的 CRP 对认知健康的老年人和 427 名在随访期间报告痴呆发作的参与者的子集的认知影响。在认知健康的参与者中,CRP 与较低水平的认知功能相关,但与随时间变化的速度无关。这种影响在 80 岁以下的参与者中显着(b = -0.09,标准误差 (SE) = 0.05,P = 0.04),但在老年参与者中则不然。在患有痴呆症的参与者中,那些具有较高 CRP 的人的认知能力下降率较小,从而导致痴呆症的诊断。结论 CRP 水平升高预示着 80 岁以下认知健康成人的认知能力较差和痴呆风险增加。相反,
更新日期:2021-06-22
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