Hepatocellular carcinoma (HCC) is one of the most frequent types of tumors worldwide. Its occurrence and development have been related to various risk factors, such as chronic infection with hepatitis B or C viruses and alcohol addiction. DNA repair systems play a critical role in maintaining the integrity of the genome. Defects in these systems have been related to increased susceptibility to various types of cancer. Multiple genetic polymorphisms in genes of DNA repair systems have been reported that may affect DNA repair capacity (DRC) and modulate risk to cancer. Several studies have been conducted to assess the role of polymorphisms of DNA repair genes on the HCC risk. Identifying these polymorphisms and their association with HCC risk may help to improve prevention and treatment strategies. In this study, we review investigations that evaluated the association between genetic polymorphisms of DNA repair genes and risk of HCC.

肝细胞癌（HCC）是世界范围内最常见的肿瘤类型之一。它的发生和发展与各种危险因素有关，例如慢性乙型或丙型肝炎病毒感染和酒精成瘾。DNA 修复系统在维持基因组完整性方面发挥着关键作用。这些系统的缺陷与对各种癌症的易感性增加有关。据报道，DNA 修复系统基因中的多种遗传多态性可能会影响 DNA 修复能力 (DRC) 并调节患癌症的风险。已经进行了几项研究来评估 DNA 修复基因多态性对 HCC 风险的作用。识别这些多态性及其与 HCC 风险的关联可能有助于改进预防和治疗策略。在这项研究中，