Silk fibroin (SF) is a natural protein polymer material approved by the US Food and Drug Administration for clinical use, such as for surgical sutures. In addition, SF has been fabricated and studied as a scaffold for tissue engineering and regenerative medicine. To append new functions to SF scaffolds and understand their in vivo behaviors, researchers have addressed modifications of SF scaffolds by using transgenic silkworm and peptide modification technologies. These modified SF scaffolds had on-target functions and showed their potential as a material for tissue engineering applications. This review summarizes the methodologies and characteristics of functionalized SF scaffolds.

丝素蛋白 (SF) 是一种天然蛋白质聚合物材料，经美国食品和药物管理局批准用于临床用途，例如用于手术缝合线。此外，SF 已被制造和研究作为组织工程和再生医学的支架。为了给 SF 支架附加新功能并了解它们的体内行为，研究人员通过使用转基因蚕和肽修饰技术解决了 SF 支架的修改问题。这些改良的 SF 支架具有靶向功能，并显示出它们作为组织工程应用材料的潜力。本综述总结了功能化 SF 支架的方法和特征。