Pseudomelanosis duodeni is a rare condition characterized by the endoscopic appearance of diffuse dark pigmentation of the duodenal mucosa. It is typically seen in older women and has been reported to be associated with hypertension, chronic renal disease, diabetes mellitus, gastrointestinal hemorrhage, and the use of medications such as oral iron, furosemide, thiazide, hydralazine, and propranolol. We present a case of pseudomelanosis duodeni appearing after 2 years of oral iron therapy in an 85-year-old woman. Although oral iron supplementation seemed the strongest possible etiology, our patient had multiple comorbidities and was on other medications that have been described as associations. The majority of individuals taking oral iron or under these clinical conditions do not develop this entity; some other factors in patients may be responsible for its occurrence.
Case Rep Gastroenterol 2021;15:689–694

中文翻译：

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口服铁剂后出现十二指肠假黑素病

十二指肠假黑素病是一种罕见的疾病，其特征在于十二指肠粘膜弥漫性深色色素沉着的内镜外观。它通常见于老年女性，据报道与高血压、慢性肾病、糖尿病、胃肠道出血以及使用口服铁剂、呋塞米、噻嗪类、肼苯哒嗪和普萘洛尔等药物有关。我们介绍了一例 85 岁女性在口服铁剂治疗 2 年后出现十二指肠假黑素病的病例。尽管口服补铁似乎是最强的病因，但我们的患者有多种合并症，并且正在服用其他被描述为相关的药物。大多数口服铁剂或在这些临床条件下服用的人不会出现这种情况；
Case Rep Gastroenterol 2021；15:689–694