Abstract

pH and GSH dual-responsive nanoparticles with fluorescence detection were successfully prepared from the polydopamine coating on the surface of mesoporous silica via disulfide bonds (MSN-SS-PDA). The average diameter of nanoparticles was about 80–100 nm with a well-ordered mesoporous structure. The outer layer of PDA was about 10.0 nm acting as a pH and GSH sensitive gatekeeper to control drug release. Doxorubicin (DOX) was loaded into mesoporous channels to evaluate the drug loading capacity and controlled release performance. TPE-4OH, an aggregation-induced emission (AIE) luminescence, was adhered to the surface of PDA for detection of drug release in real-time. The drug release from MSN-SS-PDA nanoparticles was enhanced under acidic solutions or high GSH concentrations. The fluorescence intensity decreased gradually with the drug release, which can be used for monitoring of release process. Besides, the nanoparticles exhibited good photothermal conversion capability due to the PDA layer under near-infrared light irradiation at 808 nm. These nanoparticles present a promising future for combination therapy and real-time tracking of the release process.

摘要

以介孔二氧化硅表面的聚多巴胺涂层通过二硫键（MSN-SS-PDA）成功制备了具有荧光检测的pH和GSH双响应纳米粒子。纳米粒子的平均直径约为 80-100 nm，具有有序的介孔结构。PDA 的外层约为 10.0 nm，作为 pH 和 GSH 敏感的看门人来控制药物释放。将阿霉素（DOX）加载到介孔通道中以评估载药能力和控释性能。TPE-4OH 是一种聚集诱导发射 (AIE) 发光材料，粘附在 PDA 表面，用于实时检测药物释放。在酸性溶液或高 GSH 浓度下，MSN-SS-PDA 纳米颗粒的药物释放增强。荧光强度随着药物释放逐渐减弱，可用于监控发布过程。此外，由于PDA层在808 nm的近红外光照射下，纳米粒子表现出良好的光热转换能力。这些纳米颗粒为联合治疗和释放过程的实时跟踪提供了广阔的前景。