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Coexpression of the discoidin domain receptor 1 gene with oligodendrocyte-related and schizophrenia risk genes in the developing and adult human brain
Brain and Behavior ( IF 3.1 ) Pub Date : 2021-07-29 , DOI: 10.1002/brb3.2309
Gerard Muntané 1, 2, 3, 4, 5 , Marc Chillida 1, 3 , Selena Aranda 1, 2, 3 , Arcadi Navarro 5, 6, 7 , Elisabet Vilella 1, 2, 3, 4
Affiliation  

Discoidin domain receptor tyrosine kinase 1 (DDR1) is present in multiple types of epithelial cells and is highly expressed in the nervous system. Previous studies have revealed that DDR1 is involved in schizophrenia (SCZ). Although the expression of DDR1 in oligodendrocytes has been described, its role in brain myelination is not well understood. In this study, we aimed to explore the coexpression network of DDR1 in the human brain and to compare the list of DDR1 coexpressing genes with the list of genes containing single nucleotide polymorphisms (SNPs) that are associated with SCZ.

中文翻译:

盘状结构域受体 1 基因与少突胶质细胞相关和精神分裂症风险基因在发育中和成人大脑中的共表达

盘状结构域受体酪氨酸激酶 1 (DDR1) 存在于多种类型的上皮细胞中,并在神经系统中高度表达。先前的研究表明,DDR1与精神分裂症(SCZ)有关。尽管已经描述了DDR1在少突胶质细胞中的表达,但其在脑髓鞘形成中的作用尚不清楚。在本研究中,我们旨在探索人脑中DDR1的共表达网络,并将DDR1共表达基因列表与包含与 SCZ 相关的单核苷酸多态性 (SNP) 的基因列表进行比较。
更新日期:2021-09-03
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