This article provides a broad spectrum about the nanoprodrug fabrication advances co-driven by prodrug and nanotechnology development to potentiate cancer treatment. The nanoprodrug inherits the features of both prodrug concept and nanomedicine know-how, attempts to solve underexploited challenge in cancer treatment cooperatively. Prodrugs can release bioactive drugs on-demand at specific sites to reduce systemic toxicity, this is done by using the special properties of the tumor microenvironment, such as pH value, glutathione concentration, and specific overexpressed enzymes; or by using exogenous stimulation, such as light, heat, and ultrasound. The nanotechnology, manipulating the matter within nanoscale, has high relevance to certain biological conditions, and has been widely utilized in cancer therapy. Together, the marriage of prodrug strategy which shield the side effects of parent drug and nanotechnology with pinpoint delivery capability has conceived highly camouflaged Trojan horse to maneuver cancerous threats.

中文翻译：

---

将前药纳米颗粒制成癌症治疗药物

本文广泛介绍了由前药和纳米技术发展共同驱动的纳米前药制造进步，以增强癌症治疗。纳米前药继承了前药概念和纳米医学技术的特点，试图合作解决癌症治疗中尚未开发的挑战。前药可以在特定位点按需释放生物活性药物以降低全身毒性，这是利用肿瘤微环境的特殊性质，如pH值、谷胱甘肽浓度和特定的过表达酶来实现的；或通过使用外源刺激，例如光、热和超声波。纳米技术在纳米尺度内操纵物质，与某些生物条件具有高度相关性，并已广泛应用于癌症治疗。将屏蔽母体药物副作用的前药策略与具有精确递送能力的纳米技术相结合，构想出高度伪装的特洛伊木马来操纵癌症威胁。