Combining coordination chemistry and peptide engineering offers extraordinary opportunities for developing novel molecular (supra)structures. Here, we demonstrate that the β-annulus motif is capable of directing the stereoselective assembly of designed peptides containing 2,2′-bipyridine ligands into parallel three-stranded chiral peptide helicates, and that these helicates selectively bind with high affinity to three-way DNA junctions.

中文翻译：

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由病毒 β-环三聚肽基序引导的 DNA 结合螺旋的立体选择性自组装

结合配位化学和肽工程为开发新型分子（超）结构提供了非凡的机会。在这里，我们证明了 β-环基序能够指导包含 2,2'-联吡啶配体的设计肽的立体选择性组装成平行的三链手性肽螺旋，并且这些螺旋以高亲和力选择性结合三路DNA 连接。