Bacterial infection has been attracted significant attention as it became an austere menace to public health systems. In this work, a novel thin-wall bowl-shaped particles (BSPs) were prepared by the solvent-induced phase separation method. Firstly, the copolymerization of methacrylic acid (MAA) and methyl methacrylate (MMA) were employed to synthesize amphipathic poly(methacrylic acid-co-methyl methacrylate) (PMA) chains in a solvent of EtOH/H₂O. Secondly, hydrophobic hard monomer and hydrophilic soft monomer were introduced into the amphiphilic PMA solution to polymerize and assemble within polyvinylpyrrolidone (PVP) aqueous solution, which afforded a thin-wall BSPs. Its micromorphology and composition were characterized by SEM, FT-IR, TGA and DLS. Furthermore, Ag nanoparticles (AgNPs) were loaded to the surface of thin-wall BSPs through in situ reduction of silver ion (Ag⁺). Notably, the obtained Ag@BSPs exhibited excellent antibacterial properties against E. coli and S. aureus, which has enormous application prospects in the prevention and treatment of bacterial infections.

细菌感染已经引起了极大的关注，因为它已成为对公共卫生系统的严峻威胁。在这项工作中，通过溶剂诱导相分离方法制备了一种新型薄壁碗状颗粒（BSPs）。首先，采用甲基丙烯酸（MAA）和甲基丙烯酸甲酯（MMA）共聚，在EtOH/H ₂溶剂中合成两亲性聚（甲基丙烯酸-共聚-甲基丙烯酸甲酯）（PMA）链。O. 其次，将疏水性硬单体和亲水性软单体引入两亲性 PMA 溶液中，在聚乙烯吡咯烷酮 (PVP) 水溶液中聚合和组装，得到薄壁 BSP。通过SEM、FT-IR、TGA和DLS对其显微形态和组成进行表征。此外，通过银离子 (Ag ⁺ ) 的原位还原，将银纳米颗粒 (AgNPs) 负载到薄壁 BSP 的表面。值得注意的是，所获得的Ag@BSPs对大肠杆菌和金黄色葡萄球菌表现出优异的抗菌性能，在预防和治疗细菌感染方面具有巨大的应用前景。