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Physical activity and cognitive and imaging biomarkers of Alzheimer's disease in down syndrome
Neurobiology of Aging ( IF 4.2 ) Pub Date : 2021-07-29 , DOI: 10.1016/j.neurobiolaging.2021.07.016
Victoria Fleming 1 , Brianna Piro-Gambetti 1 , Austin Patrick 2 , Matthew Zammit 2 , Andrew Alexander 2 , Bradley T Christian 2 , Benjamin Handen 3 , Annie Cohen 3 , William Klunk 3 , Charles Laymon 4 , Beau M Ances 5 , David T Plante 6 , Ozioma Okonkwo 7 , Sigan L Hartley 1
Affiliation  

Adults with Down syndrome (DS) are at risk for Alzheimer's disease. Despite sharing trisomy 21, however, there is variability in the age of disease onset. This variability may mean that other factors, such as lifestyle, influence cognitive aging and disease timing. The present study assessed the association between everyday life physical activity using an actigraph accelerometer and cognitive functioning and early Alzheimer's disease pathology via positron emission tomography amyloid-β and tau and diffusion tension imaging measures of white matter integrity in 61 non-demented adults with DS. Percent time in sedentary behavior and in moderate-to-vigorous activity were associated (negatively and positively, respectively) with cognitive functioning (r = -.472 to .572, p < 0.05). Neither sedentary behavior nor moderate-to-vigorous activity were associated with amyloid-β or tau, but both were associated with white matter integrity in the superior and inferior longitudinal fasciculus (Fractional Anisotropy: r = -.397 to -.419, p < 0.05; Mean Diffusivity: r = .400, p < 0.05). Longitudinal studies are needed to determine if physical activity promotes healthy aging in DS.



中文翻译:

唐氏综合征中阿尔茨海默病的体力活动和认知及影像学生物标志物

患有唐氏综合症 (DS) 的成年人有患阿尔茨海默病的风险。然而,尽管共有 21 三体,但发病年龄存在差异。这种可变性可能意味着其他因素,例如生活方式,会影响认知老化和疾病发生时间。本研究通过正电子发射断层扫描淀粉样蛋白-β 和 tau 以及 61 名患有 DS 的非痴呆成人白质完整性的扩散张力成像测量,评估了使用活动记录器加速度计的日常生活身体活动与认知功能和早期阿尔茨海默病病理学之间的关联。久坐行为和中度至剧烈活动的百分比时间与认知功能相关(分别为负和正)(r  = -.472 至 .572,p< 0.05)。久坐行为和中度至剧烈活动均与淀粉样蛋白-β 或 tau 无关,但两者都与上下纵束的白质完整性有关(分数各向异性:r  = -.397 至 -.419,p < 0.05;平均扩散率:r  = .400,p < 0.05)。需要进行纵向研究来确定体力活动是否会促进 DS 中的健康老龄化。

更新日期:2021-08-21
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