Thermal hazard screening of a reaction mixture that involves the use of propargyl alcohol as the reactant/solvent along with potassium hydroxide as catalyst resulted in catastrophic thermal decomposition that ruptured an accelerating rate calorimeter (ARC) test cell. Due to this critical hazard, scale-up of the chemistry was not advisible. In order to enable scale-up, further investigations into solvent and base combinations were carried out. New optimum conditions enabled the synthesis of the desired product in a safe manner. The main purpose of this manuscript is to alert the scientific community to the thermal hazards of this compound.

中文翻译：

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使用强碱炔丙醇的热危害

涉及使用炔丙醇作为反应物/溶剂以及氢氧化钾作为催化剂的反应混合物的热危害筛选导致灾难性的热分解，导致加速量热计 (ARC) 测试单元破裂。由于这种严重的危险，不建议扩大化学品的规模。为了能够扩大规模，对溶剂和碱的组合进行了进一步研究。新的最佳条件能够以安全的方式合成所需的产品。这份手稿的主要目的是提醒科学界注意这种化合物的热危害。