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RAB14 GTPase is essential for actin-based asymmetric division during mouse oocyte maturation
Cell Proliferation ( IF 8.5 ) Pub Date : 2021-07-29 , DOI: 10.1111/cpr.13104
Yuan-Jing Zou 1 , Meng-Meng Shan 1 , Hong-Hui Wang 1, 2 , Zhen-Nan Pan 1 , Meng-Hao Pan 1 , Yi Xu 1 , Jia-Qian Ju 1 , Shao-Chen Sun 1
Affiliation  

RAB14 is a member of small GTPase RAB family which localizes at the endoplasmic reticulum (ER), Golgi apparatus and endosomal compartments. RAB14 acts as molecular switches that shift between a GDP-bound inactive state and a GTP-bound active state and regulates circulation of vesicles between the Golgi and endosomal compartments. In present study, we investigated the roles of RAB14 during oocyte meiotic maturation.

中文翻译:

RAB14 GTPase 对于小鼠卵母细胞成熟过程中基于肌动蛋白的不对称分裂至关重要

RAB14 是小 GTPase RAB 家族的成员,位于内质网 (ER)、高尔基体和内体区室。RAB14 充当分子开关,在 GDP 结合的非活性状态和 GTP 结合的活性状态之间转换,并调节高尔基体和内体隔室之间的囊泡循环。在本研究中,我们研究了 RAB14 在卵母细胞减数分裂成熟过程中的作用。
更新日期:2021-09-20
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