Obesity in childhood and adolescence is a complex health issue that has detrimental effects on the physical and psychological health of the youngster, both in the short and long term. A characteristic of obesity is the associated chronic low-grade inflammation which can result in insulin resistance. Previous research suggested that biomarkers referring to such increased inflammation may help in understanding resistance to weight loss. Whether and how psychosocial factors are related with inflammation remains to be proven. The current study consisted of 594 children and adolescents (7–19 years), of whom 480 had follow-up data, who enrolled for a ten-month inpatient multidisciplinary obesity treatment consisting of healthy food routines, physical activities and psychological treatment. The purpose of the study was to explore (1) the relationship between inflammation and psychosocial stress variables (i.e., depressive symptoms, eating behavior, concerns about eating/shape/weight, insecure parent-child attachment) (correlational and multiple regression analysis), (2) whether a lifestyle intervention for obese youngsters results in decreased C-reactive protein (CRP) values (paired t-test) and (3) which psychosocial variables influence this CRP change as indication of treatment success (multiple regression analysis with change in BMI as control variable). Results showed that the psychosocial stress variables emotional eating, external eating and attachment anxiety are related to higher CRP values. Our data further suggested that a lifestyle intervention decreases the CRP values. This significant reduction in blood inflammatory marker was besides being influenced by weight loss also dependent on psychosocial variables, more specific on self-reported attachment avoidance, as this latter was related to less CRP decrease.

儿童和青春期肥胖是一个复杂的健康问题，在短期和长期都会对青少年的身心健康产生不利影响。肥胖的一个特征是相关的慢性低度炎症，可导致胰岛素抵抗。先前的研究表明，涉及这种炎症增加的生物标志物可能有助于理解对减肥的抵抗力。社会心理因素是否以及如何与炎症相关仍有待证实。目前的研究包括 594 名儿童和青少年（7-19 岁），其中 480 名有随访数据，他们参加了为期 10 个月的住院多学科肥胖治疗，包括健康饮食、体育活动和心理治疗。t检验）和（3）哪些社会心理变量影响该 CRP 变化作为治疗成功的指标（以 BMI 变化作为控制变量的多元回归分析）。结果表明，心理社会压力变量情绪化进食、外部进食和依恋焦虑与较高的 CRP 值有关。我们的数据进一步表明生活方式干预会降低 CRP 值。血液炎症标志物的显着降低除了受体重减轻的影响外，还取决于社会心理变量，更具体的是自我报告的依恋回避，因为后者与 CRP 降低较少有关。