Background

Brush or delta brush is a well-known characteristic waveform in preterm electroencephalograms. However, the longitudinal trajectory of brushes and its association with neurodevelopment remain uncertain.

Methods

We analyzed the longitudinal incidence of brushes in 36 extremely low birth weight infants without severe brain lesions and its association with neurodevelopment and white matter abnormality. Conventional eight-channel electroencephalograms were recorded at 30, 32, 36, and 40 postmenstrual weeks (PMW). Incidence of brushes was calculated as the sum of brushes from each channel separated by active sleep and quiet sleep. A developmental delay was defined as a developmental quotient of <85 assessed at corrected age of 18 months. White matter abnormalities were evaluated with term-equivalent magnetic resonance imaging.

Results

The median incidence of brushes (per minute) in 36 infants at PMW 30, 32, 36, and 40 was 16.4, 20.4, 22.5, and 1.8 during active sleep and 7.5, 10.3, 11.5, and 1.7 during quiet sleep, respectively. Among the 36 infants, 14 infants were diagnosed with developmental delay. Longitudinal trajectories of the incidence of brushes were different between the normal and the delayed development groups. Brushes were observed most frequently at 36 PMW in the delayed development group. The incidence of brushes at 36 PMW was significantly correlated with the severity of white matter abnormalities and negatively correlated with the developmental quotient.

Conclusion

The incidence of brushes at 36 PMW can be a unique predictor of early neurodevelopment in extremely low birth weight infants without severe brain lesions.

中文翻译：

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极低出生体重儿早产脑电图刷毛发生率轨迹及其与神经发育的关系

背景

刷子或三角刷是早产脑电图中众所周知的特征波形。然而，刷子的纵向轨迹及其与神经发育的关联仍然不确定。

方法

我们分析了 36 名无严重脑损伤的极低出生体重婴儿的纵向刷毛发生率及其与神经发育和白质异常的关系。在月经后 30、32、36 和 40 周 (PMW) 记录传统的八通道脑电图。刷子的发生率计算为每个通道的刷子总和，由主动睡眠和安静睡眠分开。发育迟缓被定义为在 18 个月的校正年龄时评估的发育商 <85。用术语等效磁共振成像评估白质异常。

结果

36 名 PMW 分别为 30、32、36 和 40 岁婴儿的中位刷牙发生率（每分钟）在主动睡眠期间分别为 16.4、20.4、22.5 和 1.8 次，在安静睡眠期间分别为 7.5、10.3、11.5 和 1.7 次。36名婴儿中，14名婴儿被诊断为发育迟缓。刷毛发生率的纵向轨迹在正常和延迟发育组之间是不同的。在延迟发育组中，在 36 PMW 时最常观察到刷子。36 PMW 的刷子发生率与白质异常的严重程度显着相关，与发育商数呈负相关。

结论

在没有严重脑损伤的极低出生体重婴儿中，36 PMW 的刷毛发生率可能是早期神经发育的独特预测因子。