A major problem associated with cancer treatment is resistance-prone chemotherapeutic drugs. An increasing number of studies have documented that the occurrence of resistance tends to be associated with abnormal blood vessels. In 2001, Jain proposed the vascular normalization theory, which was recently applied to the drug-resistant treatment of tumors in the clinic. Through the intervention of angiogenesis inhibitors, remodeling the structure and function of abnormal vessels can maximize the efficacy of chemotherapeutic drugs. In this review, we systematically describe the occurrence and progress of tumor angiogenesis, as well as the pathological characteristics of tumor blood vessels. Moreover, druggable targets for vascular normalization and the development of related inhibitors are also outlined.

与癌症治疗相关的一个主要问题是容易产生耐药性的化疗药物。越来越多的研究表明，阻力的发生往往与血管异常有关。2001年，Jain提出血管正常化理论，最近在临床上应用于肿瘤的耐药治疗。通过血管生成抑制剂的介入，重塑异常血管的结构和功能，可以最大限度地发挥化疗药物的疗效。在这篇综述中，我们系统地描述了肿瘤血管生成的发生和进展，以及肿瘤血管的病理特征。此外，还概述了血管正常化的药物靶点和相关抑制剂的开发。