Parechoviruses belong to the genus Parechovirus within the family Picornaviridae and are non-enveloped icosahedral viruses with a single-stranded RNA genome. Parechoviruses include human and animal pathogens classified into six species. Those that infect humans belong to the Parechovirus A species and can cause infections ranging from mild gastrointestinal or respiratory illness to severe neonatal sepsis. There are no approved antivirals available to treat parechovirus (nor any other picornavirus) infections. In this parechovirus review, we focus on the cleaved protein products resulting from the polyprotein processing after translation comparing and contrasting their known or predicted structures and functions to those of other picornaviruses. The review also includes our original analysis from sequence and structure prediction. This review highlights significant structural differences between parechoviral and other picornaviral proteins, suggesting that parechovirus drug development should specifically be directed to parechoviral targets.

副孤病毒属于小核糖核酸病毒科副孤病毒属，是具有单链 RNA 基因组的无包膜二十面体病毒。副肠孤病毒包括分为六种的人类和动物病原体。那些感染人类的​​病毒属于副肠孤病毒 A物种，并可引起从轻度胃肠道或呼吸道疾病到严重的新生儿败血症的感染。没有批准的抗病毒药物可用于治疗副肠孤病毒（或任何其他小核糖核酸病毒）感染。在这篇副肠孤病毒综述中，我们关注翻译后多蛋白加工产生的裂解蛋白产物，比较和对比它们已知或预测的结构和功能与其他小核糖核酸病毒的结构和功能。该评论还包括我们对序列和结构预测的原始分析。这篇综述强调了副孤病毒和其他小核糖核酸病毒蛋白之间的显着结构差异，表明副孤病毒药物开发应专门针对副孤病毒靶标。