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Appendage regeneration is context dependent at the cellular level
Open Biology ( IF 5.8 ) Pub Date : 2021-07-28 , DOI: 10.1098/rsob.210126
Can Aztekin 1
Affiliation  

Species that can regrow their lost appendages have been studied with the ultimate aim of developing methods to enable human limb regeneration. These examinations highlight that appendage regeneration progresses through shared tissue stages and gene activities, leading to the assumption that appendage regeneration paradigms (e.g. tails and limbs) are the same or similar. However, recent research suggests these paradigms operate differently at the cellular level, despite sharing tissue descriptions and gene expressions. Here, collecting the findings from disparate studies, I argue appendage regeneration is context dependent at the cellular level; nonetheless, it requires (i) signalling centres, (ii) stem/progenitor cell types and (iii) a regeneration-permissive environment, and these three common cellular principles could be more suitable for cross-species/paradigm/age comparisons.



中文翻译:

附属物再生在细胞水平上取决于上下文

已经研究了可以重新长出失去的附肢的物种,最终目的是开发能够使人类肢体再生的方法。这些检查强调了附肢再生通过共享的组织阶段和基因活动进行,从而假设附肢再生范式(例如尾巴和四肢)是相同或相似的。然而,最近的研究表明,尽管共享组织描述和基因表达,但这些范式在细胞水平上的运作方式不同。在这里,收集来自不同研究的结果,我认为附肢再生在细胞水平上取决于环境。尽管如此,它需要(i)信号中心,(ii)干/祖细胞类型和(iii)允许再生的环境,

更新日期:2021-07-28
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