Triglyceride glucose-body mass index (TyG-BMI) is a recently developed alternative indicator to identify insulin resistance. However, few studies have investigated the association between the TyG-BMI and nonalcoholic fatty liver disease (NAFLD). Therefore, this study aimed to study the relationship between NAFLD and the TyG-BMI in the general population and its predictive value. A cross-sectional study was conducted on 14,251 general subjects who took part in a comprehensive health examination. The anthropological characteristics and many risk factors for NAFLD were measured. After fully adjusting for confounding variables, a stable positive correlation was found between NAFLD and the TyG-BMI (OR: 3.90 per SD increase; 95% CI: 3.54 to 4.29; P-trend< 0.00001). This positive correlation was not simply linear but a stable non-linear correlation. Additionally, obvious threshold effects and saturation effects were found, in which a threshold effect occurred when the TyG-BMI was between 100 and 150; when the TyG-BMI was between 300 and 400, the corresponding NAFLD risk appeared saturated. Furthermore, receiver operating characteristic analysis showed that the TyG-BMI could better predict the risk of NAFLD than other traditional indicators [TyG-BMI (AUC): 0.886; 95% CI: 0.8797–0.8927; P < 0.0001], particularly among young and middle-aged and non-obese people. This epidemiological study is the first on the association between the TyG-BMI and NAFLD risk in the general population. In this large data set from the general population, the TyG-BMI showed an independent positive correlation with NAFLD. The discovery of the threshold effect and saturation effect between them provides a new idea to prevent and treat NAFLD.

中文翻译：

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甘油三酯葡萄糖体重指数在评估非酒精性脂肪肝中的作用：来自一般人群的见解

甘油三酯葡萄糖体重指数 (TyG-BMI) 是最近开发的用于识别胰岛素抵抗的替代指标。然而，很少有研究调查 TyG-BMI 与非酒精性脂肪肝疾病 (NAFLD) 之间的关联。因此，本研究旨在研究一般人群NAFLD与TyG-BMI的关系及其预测价值。对参加综合健康检查的 14,251 名普通受试者进行了横断面研究。测量了 NAFLD 的人类学特征和许多危险因素。在完全调整混杂变量后，发现 NAFLD 和 TyG-BMI 之间存在稳定的正相关（OR：每 SD 增加 3.90；95% CI：3.54 至 4.29；P 趋势 < 0.00001）。这种正相关不仅是线性的，而且是稳定的非线性相关。此外，还发现了明显的阈值效应和饱和效应，其中TyG-BMI在100~150之间出现阈值效应；当 TyG-BMI 介于 300 和 400 之间时，相应的 NAFLD 风险出现饱和。此外，受试者工作特征分析表明，TyG-BMI 比其他传统指标更能预测 NAFLD 风险[TyG-BMI (AUC)：0.886；95% CI：0.8797–0.8927；P < 0.0001]，尤其是在中青年和非肥胖人群中。这项流行病学研究是第一个关于 TyG-BMI 与普通人群 NAFLD 风险之间关联的研究。在这个来自普通人群的大型数据集中，TyG-BMI 与 NAFLD 呈独立的正相关。