Objective: This study aimed to compare mortality between peritoneal dialysis (PD) patients with and without cardiac valve calcification (CVC). Methods: Patients undergoing PD at the dialysis center of the Second Affiliated Hospital of Soochow University from January 1, 2009, to June 31, 2016, were included and followed through December 31, 2018. The inclusion criteria were (1) age ≥18 years and (2) PD vintage ≥1 month. The exclusion criteria were (1) a history of hemodialysis or renal transplantation before PD; (2) diagnosed congenital heart disease, rheumatic heart disease, or hyperthyroid heart disease; and (3) loss to follow-up. Differences in mortality rates were compared using a Fine-Gray proportional hazards model. Results: A total of 310 patient cases were included in this study, including 237 cases without CVC (non-CVC group). The CVC group included 59 cases with aortic valve calcification (AVC), 6 cases with mitral valve calcification (MVC), and 8 cases of AVC associated with MVC. After propensity score matching, 68 pairs were selected. The multivariate competing risk regression analysis revealed that age (hazard ratio [HR]: 1.06, 95% confidence interval [95% CI]: 1.03–1.10, p #x3c; 0.001) and CVC group (HR: 1.83, 95% CI: 1.04–3.20, p #x3c; 0.05) were independent risk factors associated with mortality. No significant difference was observed in technique survival between the 2 groups. Conclusion: CVC is an independent risk factor for mortality in PD patients.
Cardiorenal Med

中文翻译：

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腹膜透析患者的瓣膜钙化沉积和死亡率：倾向评分匹配队列分析

目的：本研究旨在比较有和没有心脏瓣膜钙化（CVC）的腹膜透析（PD）患者的死亡率。方法： 2009年1月1日至2016年6月31日在苏州大学第二附属医院透析中心接受PD治疗的患者，随访至2018年12月31日。纳入标准为（1）年龄≥18岁(2) PD 年份≥1 个月。排除标准为（1）PD前有血液透析或肾移植史；(2)确诊为先天性心脏病、风湿性心脏病或甲亢性心脏病；(3) 失访。使用 Fine-Gray 比例风险模型比较死亡率的差异。结果：本研究共纳入 310 例患者病例，其中 237 例无 CVC（非 CVC 组）。CVC组包括主动脉瓣钙化（AVC）59例，二尖瓣钙化（MVC）6例，主动脉瓣钙化（MVC）8例。倾向得分匹配后，选择了 68 对。多变量竞争风险回归分析显示年龄（风险比 [HR]：1.06，95 % 置信区间 [95% CI]：1.03–1.10，p #x3c；0.001）和 CVC 组（HR：1.83，95% CI： 1.04–3.20, p #x3c; 0.05) 是与死亡率相关的独立危险因素。两组之间的技术存活率没有观察到显着差异。结论： CVC是PD患者死亡的独立危险因素。
心肾医学