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Emerging Targets in Type 2 Diabetes and Diabetic Complications
Advanced Science ( IF 15.1 ) Pub Date : 2021-07-28 , DOI: 10.1002/advs.202100275
Sevgican Demir 1, 2, 3, 4 , Peter P Nawroth 1, 2, 3, 4 , Stephan Herzig 1, 2, 3, 4 , Bilgen Ekim Üstünel 1, 2, 3, 4
Affiliation  

Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and elevated blood glucose levels. Although a large drug portfolio exists to keep the blood glucose levels under control, these medications are not without side effects. More importantly, once diagnosed diabetes is rarely reversible. Dysfunctions in the kidney, retina, cardiovascular system, neurons, and liver represent the common complications of diabetes, which again lack effective therapies that can reverse organ injury. Overall, the molecular mechanisms of how type 2 diabetes develops and leads to irreparable organ damage remain elusive. This review particularly focuses on novel targets that may play role in pathogenesis of type 2 diabetes. Further research on these targets may eventually pave the way to novel therapies for the treatment—or even the prevention—of type 2 diabetes along with its complications.

中文翻译:

2 型糖尿病和糖尿病并发症的新兴目标

2 型糖尿病是一种代谢性慢性疾病,其特征是胰岛素抵抗和血糖水平升高。尽管存在大量药物组合来控制血糖水平,但这些药物并非没有副作用。更重要的是,糖尿病一旦确诊就很难逆转。肾脏、视网膜、心血管系统、神经元和肝脏的功能障碍是糖尿病的常见并发症,同样缺乏可以逆转器官损伤的有效疗法。总体而言,2 型糖尿病如何发展并导致不可修复的器官损伤的分子机制仍然难以捉摸。本综述特别关注可能在 2 型糖尿病发病机制中发挥作用的新靶点。对这些靶点的进一步研究最终可能为治疗甚至预防 2 型糖尿病及其并发症的新疗法铺平道路。
更新日期:2021-09-22
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