Imaging and photodynamic therapy through two-photon excitation can be applied to medical application of deep inside the tissue by minimizing light absorption by the tissue. It is the best solution that can complement the shortcomings of conventional photodynamic therapy. In addition, auto-fluorescence can be minimized, and damage to normal cells can be avoided through spatial and temporal control. To maximize the image realization and the effect of treatment, a single photosensitizer with high fluorescence quantum yields, two-photon absorption value, and good ¹O₂ or reactive oxygen species production performance must be developed. Therefore, recent research related to this topic is summarized. In addition, two-photon photosensitizers that approach selective imaging and treatment for target diseases and future challenges were discussed.

中文翻译：

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用于同步成像和光动力治疗的双光子光敏剂的最新研究趋势

通过最小化组织对光的吸收，通过双光子激发的成像和光动力疗法可以应用于组织深处的医学应用。是弥补传统光动力疗法不足之处的最佳解决方案。此外，可以最大限度地减少自发荧光，通过空间和时间控制可以避免对正常细胞的损害。为了最大限度地实现图像和治疗效果，具有高荧光量子产率、双光子吸收值和良好¹ O ₂的单一光敏剂或必须开发活性氧的生产性能。因此，总结了与该主题相关的最新研究。此外，讨论了针对目标疾病和未来挑战进行选择性成像和治疗的双光子光敏剂。