Stroke is one of the most deliberating causes of mortality and disability worldwide. Studies have implicated Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene as a genetic factor influencing stroke recovery. Still, the role of BDNF polymorphism in poststroke aphasia is relatively unclear. This review assesses the recent evidence on the association between the BDNF polymorphism and aphasia recovery in poststroke patients. The article highlights BNDF polymorphism characteristics, speech and language interventions delivered, and the influence of BNDF polymorphism on poststroke aphasia recovery. We conducted a literature search through PubMed and Google Scholar with the following terms: “brain derived-neurotrophic factor” and “aphasia” for original articles from January 2000 until June 2020. Out of 69 search results, a detailed selection process produced a total of 3 articles that met the eligibility criteria. All three studies included Val66Met polymorphism as the studied human BDNF gene. One of the studies demonstrated insufficient evidence to conclude that BDNF polymorphism plays a role in poststroke aphasia recovery. The remaining two studies have shown that Met allele genotype (either single or double nucleotides) was associated with poor aphasia recovery, in either acute or chronic stroke. Carriers of the Val66Met polymorphism of BDNF gave a poorer response to aphasia intervention and presented with more severe aphasia.

中文翻译：

---

脑源性神经营养因子多态性与中风后失语症

中风是全世界最深思熟虑的死亡和残疾原因之一。研究表明Val 66 Met脑源性神经营养因子（BDNF）基因的多态性作为影响中风恢复的遗传因素。尽管如此，BDNF 多态性在卒中后失语中的作用仍相对不清楚。本综述评估了最近关于 BDNF 多态性与卒中后患者失语症恢复之间关联的证据。文章重点介绍了 BNDF 多态性特征、提供的语音和语言干预，以及 BNDF 多态性对卒中后失语症恢复的影响。我们通过 PubMed 和 Google Scholar 对 2000 年 1 月至 2020 年 6 月的原始文章使用以下术语进行了文献搜索：“脑源性神经营养因子”和“失语症”。在 69 个搜索结果中，详细的选择过程总共产生了3篇符合入选标准的文章。所有三项研究都包括Val 66 Met多态性作为研究的人类 BDNF 基因。其中一项研究表明证据不足，无法得出 BDNF 多态性在卒中后失语症恢复中起作用的结论。其余两项研究表明，Met等位基因基因型（单核苷酸或双核苷酸）与急性或慢性中风的失语症恢复不良有关。BDNF Val 66 Met多态性的携带者对失语干预的反应较差，并且出现更严重的失语。