Long non-coding RNAs (lncRNAs) have been reported to be involved in the development of various cardiovascular diseases, including chronic heart failure (CHF). In this study, we aimed to investigate the role of ZFAS1/miR-590-3p axis in the diagnosis and prognosis of CHF. The expression of ZFAS1 and miR-590-3p in the serum samples of CHF was measured using quantitative real-time polymerase chain reaction. Pearson correlation coefficient was applied to analyze the correlation between ZFAS1 and miR-590-3p. The receiver operating characteristic (ROC) curve was used to examine the diagnostic accuracy of ZFAS1, miR-590-3p, and brain natriuretic peptide (BNP). The Kaplan–Meier curve and Cox regression analysis were used to assess the prognostic value of ZFAS1 and miR-590-3p in CHF. This study found that the serum levels of ZFAS1 were significantly higher, while miR-590-3p levels were significantly lower in CHF. ROC results indicated that the combined diagnostic accuracy of ZFAS1 + miR-590-3p + BNP was significantly higher than that of these indicators used alone. Kaplan– Meier results showed that patients with low expression of miR-590-3p or high expression of ZFAS1 had poor prognosis. In conclusion, CHF patients had increased ZFAS1 and decreased miR-590-3p expression. ZFAS1 and miR-590-3p might serve as novel non-invasive diagnostic and prognostic markers for patients with CHF.

据报道，长链非编码 RNA (lncRNA) 参与各种心血管疾病的发展，包括慢性心力衰竭 (CHF)。本研究旨在探讨 ZFAS1/miR-590-3p 轴在 CHF 诊断和预后中的作用。使用定量实时聚合酶链反应测量 CHF 血清样品中 ZFAS1 和 miR-590-3p 的表达。应用Pearson相关系数分析ZFAS1与miR-590-3p之间的相关性。采用受试者工作特征 (ROC) 曲线检查 ZFAS1、miR-590-3p 和脑利钠肽 (BNP) 的诊断准确性。Kaplan-Meier 曲线和 Cox 回归分析用于评估 ZFAS1 和 miR-590-3p 在 CHF 中的预后价值。本研究发现ZFAS1的血清水平显着升高，而 miR-590-3p 水平在 CHF 中显着降低。ROC结果表明ZFAS1+miR-590-3p+BNP联合诊断准确率明显高于单独使用这些指标。Kaplan-Meier 结果显示，miR-590-3p 低表达或 ZFAS1 高表达的患者预后较差。总之，CHF 患者 ZFAS1 增加，miR-590-3p 表达降低。ZFAS1 和 miR-590-3p 可能作为 CHF 患者的新型非侵入性诊断和预后标志物。Kaplan-Meier 结果显示，miR-590-3p 低表达或 ZFAS1 高表达的患者预后较差。总之，CHF 患者 ZFAS1 增加，miR-590-3p 表达降低。ZFAS1 和 miR-590-3p 可能作为 CHF 患者的新型非侵入性诊断和预后标志物。Kaplan-Meier 结果显示，miR-590-3p 低表达或 ZFAS1 高表达的患者预后较差。总之，CHF 患者 ZFAS1 增加，miR-590-3p 表达降低。ZFAS1 和 miR-590-3p 可能作为 CHF 患者的新型非侵入性诊断和预后标志物。