Background and Purpose:

Neuroimaging findings have been associated with adverse neurologic outcomes in children with congenital Zika virus infection. Our purpose is to describe the brain magnetic resonance imaging (MRI) of children around 3 years of age, born with congenital Zika syndrome.

Methods:

This cohort study followed 62 children born with congenital Zika syndrome who had head computed tomography (CT) performed during the first months of life. All these children had clinical, neuroimaging, and serological confirmation of congenital Zika. Around 3 years of age, these children received a brain MRI.

Results:

In 35 children, we could perform an MRI. All these children had severe impairment in neuromotor development. In general, the examinations showed the same alterations of the CT examinations: delayed myelination (82.8%), intracranial calcification (71.4%) although with decreased intensity and size as compared with previously CT examinations, ventriculomegaly (91.4%), cerebellar hypoplasia (68.5%), and cortical development abnormalities (85.8%).

Conclusion:

The serious brain alterations observed through head CT examinations in children born with congenital Zika syndrome continued to be detected through an MRI examination carried out at around 3 years of age. This indicates a poor prognosis for these children who had a severe neuromotor development delay.

中文翻译：

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先天性寨卡综合征患儿的神经影像学：一项队列研究

背景和目的：

神经影像学检查结果与先天性寨卡病毒感染儿童的不良神经系统结局相关。我们的目的是描述出生时患有先天性寨卡综合征的 3 岁左右儿童的脑磁共振成像 (MRI)。

方法：

这项队列研究跟踪了 62 名先天性寨卡综合征患儿，他们在出生后的头几个月进行了头部计算机断层扫描 (CT)。所有这些儿童都有先天性寨卡病毒的临床、神经影像学和血清学证实。大约 3 岁时，这些孩子接受了脑部核磁共振检查。

结果：

我们可以对 35 名儿童进行 MRI 检查。所有这些儿童的神经运动发育都严重受损。总的来说，这些检查显示了与 CT 检查相同的改变：髓鞘形成延迟（82.8%）、颅内钙化（71.4%），尽管与以前的 CT 检查相比强度和大小有所降低、脑室扩大（91.4%）、小脑发育不全（68.5 %）和皮质发育异常（85.8%）。

结论：

在 3 岁左右进行的 MRI 检查中，通过头部 CT 检查观察到先天性寨卡综合征患儿的严重脑部改变继续被检测到。这表明这些患有严重神经运动发育迟缓的儿童预后不良。