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The lamprey respiratory network: Some evolutionary aspects
Respiratory Physiology & Neurobiology ( IF 2.3 ) Pub Date : 2021-07-28 , DOI: 10.1016/j.resp.2021.103766
Donatella Mutolo 1 , Fulvia Bongianni 1 , Tito Pantaleo 1 , Elenia Cinelli 1
Affiliation  

Breathing is a complex behaviour that involves rhythm generating networks. In this review, we examine the main characteristics of respiratory rhythm generation in vertebrates and, in particular, we describe the main results of our studies on the role of neural mechanisms involved in the neuromodulation of the lamprey respiration. The lamprey respiratory rhythm generator is located in the paratrigeminal respiratory group (pTRG) and shows similarities with the mammalian preBötzinger complex. In fact, within the pTRG a major role is played by glutamate, but also GABA and glycine display important contributions. In addition, neuromodulatory influences are exerted by opioids, substance P, acetylcholine and serotonin. Both structures respond to exogenous ATP with a biphasic response and astrocytes there located strongly contribute to the modulation of the respiratory pattern. The results emphasize that some important characteristics of the respiratory rhythm generating network are, to a great extent, maintained throughout evolution.



中文翻译:

七鳃鳗呼吸网络:一些进化方面

呼吸是一种复杂的行为,涉及节奏生成网络。在这篇综述中,我们研究了脊椎动物呼吸节律产生的主要特征,特别是,我们描述了我们关于七鳃鳗呼吸神经调节中涉及的神经机制的作用的研究的主要结果。七鳃鳗呼吸节律发生器位于三叉神经旁呼吸组 (pTRG),与哺乳动物 preBötzinger 复合体有相似之处。事实上,在 pTRG 中,谷氨酸发挥了主要作用,但 GABA 和甘氨酸也发挥了重要作用。此外,阿片类药物、P 物质、乙酰胆碱和血清素还具有神经调节作用。两种结构都以双相反应对外源性 ATP 作出反应,并且位于其中的星形胶质细胞对呼吸模式的调节有很大的贡献。结果强调,呼吸节律生成网络的一些重要特征在很大程度上在整个进化过程中保持不变。

更新日期:2021-08-01
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